Robert U Simpson, PhD, Professor, Department of Pharmacology, 1150 W, Medical Center Dr., 1301 MSRB III, University of Michigan Medical School, Ann Arbor, MI 48109-0632, United States.
My research interests are to better understand the biochemistry and health importance of Vitamin D and to use this information to create new therapeutics. I have studied the molecular actions of the anti-proliferative effects of 1,25-Dihydroxyvitamin-D3 in cancer cells. My work also established that the vitamin D endocrine system is important for cardiovascular homeostasis. We are now elucidating the molecular actions of the vitamin D receptor to understand the processes involved in the hormones affects on heart and renin expression. I am currently President and CEO of a drug development biotech company focused on my discovery of the cardiovascular actions of vitamin D receptor agonists to clinical use.
I received a B.S. in Biochemistry from the University of California-Davis and a Ph.D. in Pharmacology from the University of Wisconsitn-Madison. I have been a tenure track faculty member of the Department of Pharmacology in the University of Michigan School of Medicine since November 1982. I have trained 7 Ph.D. students and 11 Postdoctoral Students. I have served as our department’s Graduate Student Chair and served on the department’s Graduate Student Committee for many of the 28 years I have been in the department. I focus my research on the vitamin D endocrine system and my teaching is focused on endocrine pharmacology. I have been a member of the Universities’ Rackham School of Graduate Studies Fellowship Committee and the Pharmaceutical Sciences Training Grant parent committee.
Positions and Employment
1972-1973 Laboratory Teaching Assistant, Department of Chemistry, University of California, Davis, CA, United States
1972-1973 Research Assistant, Department of Biological Chemistry, University of California, Davis, CA, United States
1973-1975 Assistant Research Scientist, Deptartment of Immunology and Serology, Hyland Laboratories, Costa Mesa, CA, United States
1975-1979 Doctoral Candidate and NIH Predoctoral Fellow, Department of Pharmacology, University of Wisconsin, Madison, WI, United States
1979-1983 NIH Postdoctoral Fellow, Dept. of Biochemistry, University of Wisconsin, Madison
1983-1990 Assistant Professor, Dept. of Pharmacology, University of Michigan Medical School
1990-1998 Associate Professor, Dept. of Pharmacology, University of Michigan Medical School
1998-present Professor, Department of Pharmacology, University of Michigan Medical School
2008-present President and CEO, Cardiavent Inc. Ann Arbor, MI
Other Experience and Professional Memberships
Member, American Association for Cancer Research
Member, American Association for Advancement of Science
Member, Sigma Xi
Member, New York Academy of Sciences
Member, American Society of Pharmacology and Experimental Therapeutics
Member, American Cancer Society
Member, American Society for Bone and Mineral Research
Member, University of Michigan Cancer Center
Member, American Heart Association
Member, NIH SBIR Study Section, Science and Technology-Drug Design and Delivery
Member, Endocrine Society
2005 Visiting Professor, Michigan State University, Department of Biochemical Nutrition
2005 Faculty Development Award, SPORE University of Michigan
2006 Invited Speaker 13th International Workshop on Vitamin D. Victoria, B.C. Canada
2007 Keynote Speaker Sigma Xi International Conference Bench to Bedside Research: Vitamin D and Heart
2008 Invited Speaker, Center for D Activated Receptor [CEDAR] Mass. Gen Hosp. Boston Symposium: Cardiovascular Diseases and Vitamin D. October 17- 18, 2008.
2009 Keynote Speaker Endocrine Society meeting. Washington DC, June 2009 Vitamin D Tour- Vitamin D Deficiency and Cardiovascular Disease.
2009 The Rachel A. Schemmel Endowed Lecture and Malcolm Trout Visiting Professor, Department of Human Nutrition, Michigan State University, East Lansing, MI
2009 Invited Speaker 14th International Workshop on Vitamin D. Brugge, Belgium
2009 Invited Speaker 7th International Symposium on Rapid Actions of Steroid Hormones. Elche, Spain