ISSN 1671-5411 CN 11-5329/R

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Volume 17 Issue 11
Dec.  2020
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Article Contents
Yao WANG, Si-Si ZHANG, Qing-Bo LV, Ya LI, Jin ZHAO, Jia HAN, Guo-Sheng FU, Wen-Bin ZHANG. Comparison of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and total cholesterol/high-density lipoprotein cholesterol for the prediction of thin-cap fibroatheroma determined by intravascular optical coherence tomography. J Geriatr Cardiol 2020; 17(11): 666-673. doi: 10.11909/j.issn.1671-5411.2020.11.003
Citation: Yao WANG, Si-Si ZHANG, Qing-Bo LV, Ya LI, Jin ZHAO, Jia HAN, Guo-Sheng FU, Wen-Bin ZHANG. Comparison of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and total cholesterol/high-density lipoprotein cholesterol for the prediction of thin-cap fibroatheroma determined by intravascular optical coherence tomography. J Geriatr Cardiol 2020; 17(11): 666-673. doi: 10.11909/j.issn.1671-5411.2020.11.003

Comparison of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and total cholesterol/high-density lipoprotein cholesterol for the prediction of thin-cap fibroatheroma determined by intravascular optical coherence tomography

doi: 10.11909/j.issn.1671-5411.2020.11.003
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  • Corresponding author:

    Wen-Bin ZHANG, Department of Cardiology, Key laboratory of biotherapy of Zhejiang Province, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University, 3 East Qingchun Road, Hangzhou, China. E-mail: 3313011@zju.edu.cn

  • Received Date: 2020-06-19
  • Accepted Date: 2020-11-05
  • Rev Recd Date: 2020-10-20
  • Available Online: 2020-11-28
  • Publish Date: 2020-11-28
  •  Background The correlation among the ratios of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL-C/ HDL-C), total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C) and thin-cap fibroatheroma has not yet been established. Methods It was a single center, retrospective observational study. In total, we recruited 421 patients (82.4% men; mean age 65.73 ± 10.44 years) with one culprit vessel which determined by intravascular optical coherence tomography (OCT). The thinnest-capped fibroatheroma (TCFA) group was defined as lipid contents in > 2 quadrants, with the thinnest fibrous cap measuring less than 65 μm. Univariate and multivariate logistic regression were carried out to explore the relationship between lipoprotein ratios, TCFA and other characteristics of plaque. To compare different ratios, the area under curve (AUC) of receiver-operating characteristic (ROC) curve was assessed. Results OCT was performed in 421 patients (TCFA group (n = 109), non-TCFA group (n = 312)). LDL-C/HDL-C in the TCFA group was significantly higher than in the non-TCFA group (2.95 ± 1.20 vs. 2.43 ± 0.92, P < 0.05), as was TC/LDL in TCFA and non-TCFA group (4.57 ± 1.58 vs. 4.04 ± 1.13, P < 0.05). Both LDL-C/HDL-C (OR: 1.002 (1.002-1.003), P < 0.05) and TC/HDL-C (OR: 1.001 (1.001-1.004), P < 0.05) were considered independent factors for the prediction of TCFA according to the logistic regression. Based on the AUC comparison, LDL-C/ HDL-C and TC/HDL-C had no significant difference statistically (LDL-C/HDL-C AUC: 0.63; TC/HDL-C AUC: 0.61; P = 0.10) for the prediction of TCFA. Conclusions LDL-C/HDL-C and TC/HDL-C could be the independent factors for predicting the presence of TCFA, indicating coronary plaque vulnerability in CAD patients. Moreover, TC/HDL-C also showed a comparative performance for the prediction of TCFA as LDL-C/HDL-C.
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    *The first three authors contributed equally to this article
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