Please cite this article as: ZHANG YJ, SONG JJ, ZHAN JH, ZHOU CL, LI A, WANG MQ, LI BJ, DING CC, ZHANG YW, TAN ZH, CHENG ZH, HUANG X. Alcohol drinking triggered decrease of oxidative balance score is associated with high all-cause and cardiovascular mortality in hypertensive individuals: findings from NHANES 1999–2014. J Geriatr Cardiol 2024; 21(8): 779−790. DOI: 10.26599/1671-5411.2024.08.002.
Citation: Please cite this article as: ZHANG YJ, SONG JJ, ZHAN JH, ZHOU CL, LI A, WANG MQ, LI BJ, DING CC, ZHANG YW, TAN ZH, CHENG ZH, HUANG X. Alcohol drinking triggered decrease of oxidative balance score is associated with high all-cause and cardiovascular mortality in hypertensive individuals: findings from NHANES 1999–2014. J Geriatr Cardiol 2024; 21(8): 779−790. DOI: 10.26599/1671-5411.2024.08.002.

Alcohol drinking triggered decrease of oxidative balance score is associated with high all-cause and cardiovascular mortality in hypertensive individuals: findings from NHANES 1999–2014

  • BACKGROUND  Oxidative stress is closely associated with hypertensive outcomes. The oxidative balance score (OBS) measures oxidative stress exposure from dietary and lifestyle elements. The objective of this study was to investigate the association between OBS and mortality in hypertensive patients.
    METHODS  This study included 7823 hypertensive patients from the National Health and Nutrition Examination Survey (NHANES) 1999–2014. Several models, including Cox regression, restricted cubic splines (RCS), Kaplan‒Meier survival analysis, subgroup, and sensitivity analyses, were exploited to investigate the relationship between OBS and the risk of mortality.
    RESULTS  Controlling for all potential confounders, a significantly inverse association was observed between elevated OBS and all-cause hazard ratio (HR) = 0.90, 95% CI: 0.85–0.95 and cardiovascular mortality (HR = 0.85, 95% CI: 0.75–0.95). With adjustment for covariates, significant associations between lifestyle OBS and mortality risks diminished, whereas associations between dietary OBS and these mortality risks remained robust (all-cause mortality: HR = 0.91, 95% CI: 0.86–0.96; cardiovascular mortality: HR = 0.85, 95% CI: 0.76–0.96). RCS demonstrated a linear relationship between OBS and all-cause and cardiovascular mortality risk (Pnonlinear = 0.088 and Pnonlinear = 0.447, respectively). Kaplan‒Meier curves demonstrated that the mortality rate was lower with a high OBS (P < 0.001). The consistency of the association was demonstrated in subgroup and sensitivity analyses. RCS after stratification showed that among current drinkers, those with higher OBS had a lower risk of mortality compared with former or never drinkers.
    CONCLUSIONS  In hypertensive individuals, there was a negative association between OBS and all-cause and cardiovascular mortality. Encouraging hypertensive individuals, especially those currently drinking, to maintain high levels of OBS may be beneficial in improving their prognosis.
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