Rui WANG, Yao-Dong DING, Wen GAO, Yu-Qiang PEI, Jia-Xin YANG, Ying-Xin ZHAO, Xiao-Li LIU, Hua SHEN, Shuo ZHANG, Lei YU, Hai-Long GE. Serum microRNA-204 levels are associated with long-term cardiovascular disease risk based on the Framingham risk score in patients with type 2 diabetes: results from an observational study[J]. Journal of Geriatric Cardiology, 2020, 17(6): 330-337. DOI: 10.11909/j.issn.1671-5411.2020.06.006
Citation: Rui WANG, Yao-Dong DING, Wen GAO, Yu-Qiang PEI, Jia-Xin YANG, Ying-Xin ZHAO, Xiao-Li LIU, Hua SHEN, Shuo ZHANG, Lei YU, Hai-Long GE. Serum microRNA-204 levels are associated with long-term cardiovascular disease risk based on the Framingham risk score in patients with type 2 diabetes: results from an observational study[J]. Journal of Geriatric Cardiology, 2020, 17(6): 330-337. DOI: 10.11909/j.issn.1671-5411.2020.06.006

Serum microRNA-204 levels are associated with long-term cardiovascular disease risk based on the Framingham risk score in patients with type 2 diabetes: results from an observational study

  • Background Previous studies have demonstrated that microRNA-204 (miR-204) is involved in atherosclerosis and vascular calcification. However, the value of miR-204 as the predictive biomarker for cardiovascular disease (CVD) remains unclear. We aimed to evaluate the association between the circulating miR-204 level and ten-year CVD risk based on the Framingham risk score (FRS). Methods In this retrospective study, we enrolled 194 consecutive patients with type 2 diabetes mellitus (T2DM) without CVD in Beijing Anzhen Hospital between January 2015 and September 2016. We used the FRS to evaluate the risk of CVD for each patient. Circulating miR-204 levels were measured by quantitative real-time polymerase chain reaction. Results Circulating miR-204 levels were significantly lower in the group of patients (0.49 ± 0.13) at high risk of CVD (FRS > 20%) than in the low (FRS P P P = 0.001). Receiver-operating characteristic curve analysis showed that the circulating miR-204 level can predict the high risk of CVD with higher specificity than the traditional risk factor of high systolic blood pressure or the protective factor of high-density lipoprotein cholesterol. Conclusions Our study demonstrated that patients with lower circulating miR-204 levels were at high risk for CVD. After adjustment for potential confounders, miR-204 was independently associated with CVD in patients with T2DM.
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