The relationship between NT-proBNP and Depression in Patients with Heart Failure

We read the article entitled ‘Depression is associated with increased C-reactive protein levels in patients with heart failure and hyperuricemia’. In this article WANG, et al.1 reported that serum hs-CRP may be an independent marker for severity of depression in heart failure patients with hyperuricemia. The authors suggested that the relationship between the role of inflammation in the pathogenesis of depression and heart failure may help to devise new strategies. However, we have some suggestions about this study: there was no control group and plasma NT-proBNP is not investigated in study group.