OBJECTIVE To examine the trends in patient characteristics and clinical outcomes over a ten-year period and to analyse the predictors of mortality in octogenarians undergoing percutaneous coronary intervention (PCI) in our centre.
METHODS A total of 782 consecutive octogenarians (aged 80 and above) were identified from a prospectively collected PCI database within our non-surgical, medium volume centre between 1st January 2007 and 31st December 2016. This represented 10.9% of all PCI procedures performed in our centre during this period. We evaluated the demographic and procedural characteristics of the cohort with respect to clinical outcomes (all-cause in-hospital and 1-year mortality, in-hospital complication rates, duration of hospital admission, coronary disease angiographic complexity and major co-morbidities). The cohort was further stratified into three chronological tertiles (January 2007 to July 2012, 261 cases; August 2012 to May 2015, 261 cases; June 2015 to December 2016, 260 cases) to assess for differences over time. Predictors of mortality were identified through a multivariate regression analysis.
RESULTS The number of octogenarians undergoing PCI increased nearly ten-fold over the studied period. Despite this, there were no significant differences in clinical outcomes or patient characteristics, except for the increased use of trans-radial vascular access 11.9% in first tertile vs. 73.2% in third tertile (P < 0.0001). The all-cause in-hospital (5.8% vs. 4.6% vs. 3.8%, P = 0.578) and 1-year mortality (12.4% vs. 12.5% vs. 14.4%, P = 0.746) remained constant in all three tertiles respectively. Six independent predictors of mortality were identified - increasing age HR = 1.12 (1.03−1.22), P = 0.008, cardiogenic shock HR = 16.40 (4.04–66.65), P < 0.0001, severe left ventricular impairment HR = 3.52 (1.69−7.33), P = 0.001, peripheral vascular disease HR = 2.73 (1.22−6.13), P = 0.015, diabetes HR = 2.59 (1.30−5.17), P = 0.007 and low creatinine clearance HR = 0.98 (0.96−1.00), P = 0.031.
CONCLUSION This contemporary observational study provides a useful insight into the real-world practice of PCI in octogenarians.
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