Li-Hui ZHENG, Shang-Yu LIU, Feng HU, Er-Peng Liang, Ling-Min WU, Hong-Lei WANG, Ammar M Killu, Yan YAO. Association between big endothelin-1 and CHADS2/CHA2DS2-VASc scores in non-valvular atrial fibrillation[J]. Journal of Geriatric Cardiology, 2019, 16(11): 812-817. DOI: 10.11909/j.issn.1671-5411.2019.11.003
Citation: Li-Hui ZHENG, Shang-Yu LIU, Feng HU, Er-Peng Liang, Ling-Min WU, Hong-Lei WANG, Ammar M Killu, Yan YAO. Association between big endothelin-1 and CHADS2/CHA2DS2-VASc scores in non-valvular atrial fibrillation[J]. Journal of Geriatric Cardiology, 2019, 16(11): 812-817. DOI: 10.11909/j.issn.1671-5411.2019.11.003

Association between big endothelin-1 and CHADS2/CHA2DS2-VASc scores in non-valvular atrial fibrillation

  • Background Endothelial function, as measured by big endothelin-1 (ET-1), has been demonstrated to be useful in predicting adverse long-term events in patients with cardiovascular disease. Nevertheless, there are little data about the association between big ET-1 and thromboembolism risk in atrial fibrillation (AF). We aimed to investigate the relationship between big ET-1 and CHADS2/CHA2DS2-VASc scores used for evaluating thromboembolic risk in patients with non-valvular AF. Methods The study population consisted of 238 consecutive AF patients (67.6% with paroxysmal AF and 32.4% with persistent AF). The patients were divided into two groups (high- or low-intermediate risk group) based on CHADS2 and CHA2DS2-VASc scores (score ≥2 or 2/CHA2DS2-VASc scores were compared between groups. The association between big ET-1 levels and CHADS2/CHA2DS2-VASc score was assessed. Multivariate logistic regression analysis was performed to identify independent predictors of CHADS2/CHA2DS2-VASc scores. Results The high CHADS2/CHA2DS2-VASc score group had older age, higher big ET-1 levels, and enlarged left atrial diameter than the low CHADS2/CHA2DS2-VASc score group (P 2/CHA2DS2-VASc scores odds ratio (OR) = 2.545 and OR = 3.816; both P Conclusions Our study indicates that in non-valvular AF, big ET-1 was significantly correlated with CHADS2/CHA2DS2-VASc scores and an independent predictor of high CHADS2/CHA2DS2-VASc scores. Big ET-1 may serve as a useful marker for risk stratification in this setting.
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