Da–Cen LIN, Jia–Bing LIN, Zhou CHEN, Rong CHEN, Chun–Yu WAN, Shao–Wei LIN, Qi–Shuang RUAN, Huang–Yuan LI, Si–Ying WU. Independent and combined effects of environmental factors and miR-126, miR-143, and miR-145 on the risk of coronary heart disease[J]. Journal of Geriatric Cardiology, 2017, 14(11): 688-695. DOI: 10.11909/j.issn.1671-5411.2017.11.004
Citation: Da–Cen LIN, Jia–Bing LIN, Zhou CHEN, Rong CHEN, Chun–Yu WAN, Shao–Wei LIN, Qi–Shuang RUAN, Huang–Yuan LI, Si–Ying WU. Independent and combined effects of environmental factors and miR-126, miR-143, and miR-145 on the risk of coronary heart disease[J]. Journal of Geriatric Cardiology, 2017, 14(11): 688-695. DOI: 10.11909/j.issn.1671-5411.2017.11.004

Independent and combined effects of environmental factors and miR-126, miR-143, and miR-145 on the risk of coronary heart disease

  • Objective to evaluate the effects of environmental factors and microRNAs (miRNAs) (miR-126, miR-143, and miR-145) on the risk of coronary heart disease (CHD). Methods A frequency-matched case-control study (450 patients, 450 controls) was conducted from April 2014 to December 2016 in Fuzhou City, China. Environmental factors were investigated using a self-administered questionnaire, and the expression levels of miR-126, miR-143, and miR-145 were determined by quantitative real-time Polymerase Chain Reaction (PCR) in peripheral blood mononuclear cells. Unconditional logistic regression models were used for statistical evaluation. Results Alcohol consumption, high-salt diets, high-intensity work, and lack of physical activity were significantly associated with increased CHD risk, whereas light diet was significantly associated with decreased risk. MiR-126, miR-143, and miR-145 were highly expressed in the CHD group compared with the control group. After adjustment for other environmental factors, unconditional logistic regression results revealed that miR-126, miR-143, and depression were the independent risk factors of CHD, and light diet was the independent protective factor of CHD. Conclusions Our data suggest that a family history of CHD, anxiety, and alcohol consumption was significantly associated with increased CHD risk, whereas light diet was significantly associated with decreased risk. Furthermore, miR-126 and miR-143 in combination with several risk factors, could play a joint role in the development of CHD. Therefore, it is necessary to manage patients with CHD in all directions and multiple level.
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