Li-Hui ZHENG, Wei SUN, Yan YAO, Bing-Bo HOU, Yu QIAO, Shu ZHANG. Associations of big endothelin-1 and C-reactive protein in atrial fibrillation[J]. Journal of Geriatric Cardiology, 2016, 13(5): 465-470. DOI: 10.11909/j.issn.1671-5411.2016.05.005
Citation: Li-Hui ZHENG, Wei SUN, Yan YAO, Bing-Bo HOU, Yu QIAO, Shu ZHANG. Associations of big endothelin-1 and C-reactive protein in atrial fibrillation[J]. Journal of Geriatric Cardiology, 2016, 13(5): 465-470. DOI: 10.11909/j.issn.1671-5411.2016.05.005

Associations of big endothelin-1 and C-reactive protein in atrial fibrillation

  • Background Atrial fibrillation (AF) is associated with inflammation and endothelial dysfunction. However, the association between inflammation (as indexed by high-sensitivity C-reactive protein, hs-CRP) and endothelial function as indexed by big endothelin-1 (ET-1) in AF patients remains unclear. Methods We enrolled 128 patients with lone AF, among which 83 had paroxysmal AF, and 45 had persistent AF. Eighty-two age- and gender-matched controls of paroxysmal supraventricular tachycardia without AF history were evaluated. Plasma hs-CRP, big ET-1 levels and other clinical characteristics were compared among the groups. Results Patients with persistent AF had higher hs-CRP concentrations than those with paroxysmal AF (P P P > 0.05), and both groups had higher big ET-1 levels than controls (P P P r = 0.563, P r = 0.094, P Conclusions Both plasma hs-CRP and big ET-1 levels are elevated in lone AF patients, and are associated with AF. In paroxysmal lone AF patients, there were significant positive correlations between plasma hs-CRP level and big ET-1 level.
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