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Bao-Feng Yang

NAME:     Bao-Feng Yang

DATE OF BIRTH:    November 27, 1957

POSITION:      President of Harbin Medical University, Harbin, Heilongjiang Province, China

ADDRESS:       Harbin Medical University, 157 Baojian Road, Harbin, Heilongjiang Province, China 150081

E-MAIL:  yangbf@ems.hrbmu.edu.cn

EDUCATION:

Research Fellow, Pharmacology, Research Center, Montreal Heart Institute, Montreal. 1995-1996

Post doctor, Pharmacology, Tsukuba Research Laboratories, Eisai Co., Ltd. Tsukuba-shi Ibaraki-ken 300-26, Japan.  1990-1992

Ph.D. Pharmacology, Tongji Medical University, Wuhan, China 1985-1988

M.Sc. Pharmacology, Harbin Medical University,  Harbin, China.1982-1985

Pharm.C. Pharmacy. Shenyang Pharmacy University, Shenyang, China. 1976-1980

WORK EXPERIENCE:

2001-now President, Harbin Medical University

1998-2001 Vice President, Harbin Medical University

1997-1998 Dean, Basic Medical Sciences College of Harbin Medical University

1994-now Professor, Director of Pharmacology Department, Harbin Medical University, Harbin, China.

Associate Professor, Pharmacology, Harbin Medical University, Harbin, China.

Research Scientist, Pharmacology, Tsukuba Research Laboratories, Eisai Co. ,Ltd. Tsukuba-shi Ibaraki-ken 300-26, Japan

Lecturer, Pharmacology, Tongliao Medical University, Tongliao , China.

Social Service

(A) Chinese Medical Association        Vice President

(B) Chinese Academy of Engineering    Member

(C) Chinese Pharmacologic Society      Vice President

(D) Heilongjiang Association for Science and Technology  Vice President

(E) National Program on Key Basic Research Project     Chief Scientist

AWARDS

Prize awarded by Wu Jieping-Paul in 2000 for the Study on relationship between antiarrhythmic compounds of herbs and K+ channels

Prize awarded by Education Ministry of China in 2000 for the Study on best targets of antiarrhythmic drugs

Prize awarded by Education Ministry of China in 2003 for the Study on relationship between subtypes of Ach receptors in hearts and potassium channels

Prize awarded by Education Ministry of China in 2003

Prize awarded by the National Natural Science Award of China in 2004 for the Studies on ion channel  targets of antiarrhythmic drugs

Prize for Scientific and Technological Achievements of Ho Leung Ho Lee Foundation in 2008

Prize for the highest Scientific and Technological Achievements of Heilongjiang in 2009

Representatives of the article (nearest three years)

Zhao J, Li J, Li W, Li Y, Shan H, Gong Y, Yang B. Effects of spironolactone on atrial structural remodelling in a canine model of atrial fibrillation produced by prolonged atrial pacing. Br J Pharmacol. 2010 Apr;159(8):1584-94.

Dong DL, Chen C, Huo R, Wang N, Li Z, Tu YJ, Hu JT, Chu X, Huang W, Yang BF. Reciprocal repression between microRNA-133 and calcineurin regulates cardiac hypertrophy: a novel mechanism for progressive cardiac hypertrophy. Hypertension. 2010 Apr;55(4):946-52

Zhao J, Su Y, Zhang Y, Pan Z, Yang L, Chen X, Liu Y, Lu Y, Du Z, Yang B. Activation of cardiac muscarinic M3 receptors induces delayed cardioprotection by preserving phosphorylated connexin43 and up-regulating cyclooxygenase-2 expression. Br J Pharmacol. 2010 Mar;159(6):1217-25.

Hongli Shan, Yong Zhang, Yanjie Lu, Ying Zhang, Zhenwei Pan, Benzhi Cai, Ning Wang, Xuelian Li, Tieming Feng, Yuan Hong and Baofeng Yang. Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines. Cardiovascular Research 2009; 83(1): 465-472.

Shan H, Li X, Pan Z, Zhang L, Cai B, Zhang Y, Xu C, Chu W, Qiao G, Li B, Lu Y, Yang B. Tanshinone IIA protects against sudden cardiac death induced by lethal arrhythmias via repression of microRNA-1. Br J Pharmacol. 2009 ;158(5):1227-35

Li X, Chu W, Liu J, Xue X, Lu Y, Shan H, Yang B. Antiarrhythmic properties of long-term treatment with matrine in arrhythmic rat induced by coronary ligation. Biol Pharm Bull. 2009 Sep; 32(9):1521-6.

Cai B, Shan L, Gong D, Pan Z, Ai J, Xu C, Lu Y, Yang B. Homocysteine modulates sodium channel currents in human atrial myocytes. Toxicology 2009; 256(3): 201-206.

Zhao XY, Qiao GF, Li BX, Chai LM, Li Z, Lu YJ, Yang BF. Hypoglycaemic and hypolipidaemic effects of emodin and its effect on L-type calcium channels in dyslipidaemic-diabetic rats. Clinical and Experimental Pharmacology and Physiology 2009; 36(1): 29-34.

Lu Y, Zhang Y, Shan H, Pan Z, Li X, Li B, Xu C, Zhang B, Zhang F, Dong D, Song W, Qiao G, Yang B. MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction: a new mechanism for ischaemic cardioprotection. Cardiovasc Res. 2009;84(3):434-441.

Zhao XL, Gu DF, Qi ZP, Chen MH, Wei T, Li BX, Yang BF. Comparative effects of sophocarpine and sophoridine on hERG K+ channel. European Journal of Pharmacology 2009; 607(1-3): 15-22.

Dongmei Gong, Yong Zhang, Benzhi Cai, Qingxin Meng, Shulin Jiang, Xia Li, Luchen Shan, Yanyan Liu, Guofen Qiao, Yanjie Lu and Baofeng Yang,. Characterization and comparison of Na+, K+ and Ca2+ currents between myocytes from human atrial right appendage and atrial septum. Cell Physiol Biochem. 2008;21(5-6):385-94.

Zhao XY, Li GY, Liu Y, Chai LM, Chen JX, Zhang Y, Du ZM, Lu YJ, Yang BF. Resveratrol protects against arsenic trioxide-induced cardiotoxicity in vitro and in vivo. Br J Pharmacol. 2008 May;154(1):105-13.

Baofeng Yang, Yanjie Lu, and Zhiguo Wang. Control of cardiac excitability by microRNAs. Cardiovascular Research. 2008; 79: 571–580.

De-Li Dong, Chang Chen, Wei Huang, Yan Chen, Xiao-Lan Zhang, Zhe Li, Yue Li, Bao-Feng Yang. Tricarbonyldichlororuthenium (II) dimer (CORM2) activates non-selective cation current in human endothelial cells independently of carbon monoxide releasing. European Journal of Pharmacology. 2008;590: 99-104.

Chaoqian Xu, Yanjie Lu, Zhenwei Pan, Wenfeng Chu, Xiaobin Luo, Huixian Lin, Jiening Xiao, Hongli Shan, Zhiguo Wang and Baofeng Yang. The muscle-specific microRNAs miR-1and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes. Journal of Cell Science,2007;120 (17):3045-3052.

Yunlong Bai, Jingxiong Wang, Hongli Shan, Yanjie Lu, Ying Zhang, Xiaobin Luo, Baofeng Yang* and Zhiguo Wang*. Sphingolipid Metabolite Ceramide Causes Metabolic Perturbation Contributing to HERG K+ Channel Dysfunction. Cell Physiol Biochem, 2007, 20:429-440.

Ben-Zhi Cai, Dong-Mei Gong, Yu Liu, Zhen-Wei Pan, Chao-Qian Xu, Yun-Long Bai, Guo-Fen Qiao, Yan-Jie Lu, Bao-Feng Yang. Homocysteine inhibits potassium channels in human atrial myocytes. Clin Exp Pharmacol Physiol, 2007, 34(9):851-855.

Xiao-Yan Zhao, Guo-Yu Li, Yan Liu, Li-Min Cai, Jun-Xia Chen, Yong Zhang, Yan-Jie Lu, Bao-Feng Yang. Resveratrol protects against arsenic trioxide-induced cardiotoxicity in vitro and in vivo.  British journal of pharmacology, 2008,154: 105-113.

Baofeng Yang, Huixian Lin, Jiening Xiao, Yanjie Lu, Xiaobin Luo, Baoxin Li, Ying Zhang, Chaoqian Xu, Yunlong Bai, Huizhen Wang, Guohao Chen & Zhiguo Wang. The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. Nature Medicine, 2007; 13(4):486-491.

Yue Li, Wei-min Li, Yong-tai Gong, Bao-xin Li, Wei Liu, Wei Han, Deli Dong, Li Sheng, Jing-yi Xue, Li Zhang, Shan Chu, Bao-feng Yang. The effects of cilazapril and valsartan on the mRNA and protein expressions of atrial calpains and atrial structural remodeling in atrial fibrillation dogs. Basic Res Cardiol, 2007102245-256.