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Yue-Jin Yang

Yue-Jin Yang, Male, born in mar 1958, MD, PhD,FACC, doctoral supervisor (authorized in Jun 1998) , Youth member of the Chinese Medical Association

Work unit:       Cardiovascular Institute and Fu Wai Cardiovascular Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC)

Address: 167# Bei Li Shi Rd, West City District, Beijing

Post Code:        100037

Professional Title:   Chief Physician, Professor, Research Fellow, Tutor of Medicine Doctor Candidate

Present Position:      Director of Cardiovascular Department and deputy dean

Education

1978.3. -1982.12.         Medical Bachelor degree, Suzhou Medical College

1984.9. – 1989.9.         M.D., Ph.D. degree, Graduate School of CAMS & PUNIC

1991.7. – 1992.9.         Fellow, Echocardiography Lab. Of Cardiology Dept., University of Ottawa Heart Institute, Canada

1997.7 – 1997.12.        Visiting professor, Cath Lab. of Coronary Intervention, Stanford University Hospital, USA.

Professional Experience

1984.9-1989.9     Resident and Chief resident of cardiology, Cardiovascular Institute and Fu Wai Hospital, CAMS & PUMC

1989.10-1993.4   Attending Physician of Cardiology, Cardiovascular Institute and Fu Wai Hospital, CAMS & PUMC

1993.5-1996.4     Associate Professor in Cardiology, Cardiovascular Institute and Fu Wai Hospital, CAMS & PUMC (Special Offer)

1996.5-Now       Professor in cardiology, Cardiovascular Institute and Fu Wai Hospital, CAMS & PUMC (Special Offer)

1984.4-Now       Doctoral supervisor of Cardiology Dept., Cardiovascular Institute and Fu Wai hospital, CAMS & PUMC, Beijing, P. R. China

2002.9-Now       Deputy chief of Cardiology Dept., Cardiovascular Institute and Fu Wai hospital, CAMS & PUMC, Beijing, P. R. China

2003.7-2009.1     Director of Cardiology Dept., Cardiovascular Institute and Fu Wai hospital, CAMS & PUMC, Beijing, P. R. China

2009.2-Now       Director of the Center for Coronary Heart Disease Diagnosis and Treatment, Cardiovascular Institute and Fu Wai hospital, CAMS & PUMC, Beijing, P. R. China

Research Experience

Taking Charge of Research Projects

1.          Experimental study of left ventricular remodeling after acute myocardial infarction. (1993, Granted by PUMC & CAMS)

2.          Prevention and therapy of left ventricular remodeling after acute myocardial infarction. (1994, Granted by Ministry of Education, China)

3.          Detecting hibernating myocardium and predicting cardiac function after revascularization by Isosorbide Dinitrate (Isoket) echocardiography. (1995, granted by PUMC & CAMS)

4.          Distinguishing hibernating myocardium by low-dose dobutamine stress echocardiography. (1995, Granted by Ministry of Public Health, China)

5.          Distinguishing hibernating myocardium by low-dose dobutamine- Isosorbide Dinitrate (Isoket) stress echocardiography. (1996, Granted by Ministry of Public Health, China)

6.          The expression of matrix metalloproteinases, tissue inhibitor of metalloproteinase and collagen and the relation to left ventricular remodeling (1999, Granted by Ministry of Education, China)

7.          The roles of expression of matrix metalloproteinases, tissue inhibitor of metalloproteinase and collagen in left ventricular remodeling and heart failure. (2000, Granted by National Basic Research Program [973 Program], Ministry of Science and Technology, China)

8.          The role of phospholipase B in post-infarction remodeling and associated signaling transduction. (2001, Granted by Ministry of Science and Technology, China)

9.          Prevalence and standardized prevention and treatment in China. (2001, Granted by “National 10th five-year projects”, China)

10.        Evaluating operating manual in preventing and treating cardiovascular diseases and tumor. (2001, Granted by Ministry of Science and Technology, China)

11.       The effects of traditional Chinese medicine, Tongxinluo, on protecting micro-circulation after acute myocardial infarction and reperfusion. (2004, Granted by Ministry of Science and Technology, China)

12.       Early diagnosis of heart failure. (2005, Granted by Bureau of Public Health of Beijing, China)

13.       The effects and mechanisms of traditional Chinese medicine, Tongxinluo, on protecting microvessels after acute myocardial infarction and reperfusion. (2006, Granted by Ministry of Science and Technology, China)

14.       The prevention of post-revascularization ischemic/reperfusion injuries and long-term prognosis. (2006, Granted by Ministry of Science and Technology, China)

15.       Population-based monitoring of heart failure and establishment of standardized network of prevention and treatment. (2006, Granted by Bureau of Science and Technology of Beijing, China)

16.       The role of endothelial connection in myocardial no-reflow after reperfusion and mechanisms study. (2006, Granted by Ministry of Science and Technology, China)

17.        The prospective study of evaluating standardized clinical indexes in diagnosis of coronary heart disease. (2006, Granted by “National 11th five-year projects”, China)

18.       The trans-differentiation of bone marrow mesenchymal stem cells and transplantation to treat myocardial infarction. (2008, Granted by National Basic Research Program [863 Program], Ministry of Science and Technology, China)

Participating Research Projects

1.          The comparative study of thrombolysis in acute myocardial infarction. (1991, Granted by “National 8th five-year projects”, China)

2.          The study of secondary prevention of acute myocardial infarction. (1991, Granted by “National 8th five-year projects”, China)

3.          The preventative study of restenosis after coronary intervention. (1991, Granted by “National 8th five-year projects”, China)

4.          The comparative study of r-tPA and urokinase (TUCC) in thrombolysis of acute myocardial infarction. (1991, Granted by “National 8th five-year projects”, China)

5.          The randomized, crosswise, controlled and multi-center phase II clinical trials of evaluating the safety and effects of injected recombinant human brain natriuretic peptide in decompensatory congestive heart failure.

6.          The phase II clinical trials of evaluating the safety of injected recombinant human brain natriuretic peptide in decompensatory congestive heart failure.

7.          The multi-center, randomized, paralleled, and controlled phase II clinical trial to compare Levosimendan with dobutamine hydrochloride in treating decompensatory chronic heart failure patients.

8.          The phase II clinical trial to evaluate safety and effect of recombinant human nerogulin in treating decompensatory chronic heart failure patients.

Academic Activity

Member of Beijing Committee of Chinese Cardiovascular Association

Member of Cardiovascular Professional Committee of Chinese Medical Association

Chief Member of Medical Committee of Beijing Medical Reward Fund

Editor of the Chinese Journal of Cardiology

Editor of the Chinese Medical Journal

Member of Evaluation Committee of Chinese Medical Technology Reward and Chinese Medical Youth Reward, Chinese Medical Association

Editor of Chinese Journal of Interventional Cardiology

Editor of Cardiopulmonary Disease Forum

Deputy editor in chief of Chinese Journal of Difficult and Complicated Diseases

Editor of Chinese Circulation Journal

Editor of Chinese Geriatric Journal of Heart and Brain Vessel Diseases

Editor of Chinese Journal of Medicine

Editor of Molecular Cardiology of China

Editor of Chinese Clinical Medical Collection

Associate Chief editor of Chinese Journal of Practical Internal Medicine (2005)

Editor of Chinese Journal of Medicine (2006)

Associate Editor of Chinese Journal of Difficult and Complicated Cases (2006)

Editor of Chinese Journal of Interventional Cardiology (2006)

Associate Chairmen of Cardiovascular Physician Committee of Chinese Medical Doctor Association (2006)

Editor of China Medical News (2006)

Editor of Chinese Journal of Modern Clinical Medicine (2007)

Rewards

1.          The reproducibility of apical biplane 2-DE in quantitative determining left ventricular volumes and the application in coronary diseases was rewarded the third class reward of Technical Progress by Union Medical University in 1991 (Rank 2 as the investigator for concrete work).

2.          Emergent treatment of AMl complicated by severe cardiogenic shock by PTCA was rewarded the first class reward of Union Medical University by Fuwai Hospital in 1993-1994, rank 4.

3.          Three successful cases by use of ultra high-dose dopamine combined with low-dose sodium nitroprussiate in treatment of AMl complicated by severe cardiogenic shock was rewarded the second class reward of Medical Achievement by Fuwai Hospital in 1993-1994, rank 1.

4.          The left ventricular performance and remodeling in early AMI was rewarded the third class reward of excellent paper by the third Shanghai Squibb Medical Fund (1995), rank 1.

5.          Clinical Study of AMI LV remodulating was rewarded as the third class reward of Medical Achievement by Fuwai Hospital (1997), rank 1.

6.          Evaluation of efficacy of PTCA by intravascular echocardiography was rewarded the third class reward of Medical Achievement by the Union Medical University in 1995-1996 (1997) and the second class reward of Medical Achievement by Fuwai Hospital in 1995-1996 (1997), rank 4.

7.          The comparison of Isoket and Low-dose dobutamine echocardiography in identification of hibernating myocardium was rewarded the second class reward for the fourth time (1997), rank 1.

8.          He was rewarded as Young Physician of SACKLER Fund of USA (1999).

9.          Coronary arterial intervention therapy by radial artery pathway by Qiao Shubing, Yao Min, Gao Runlin, Chen Jilin, Yang Yuejin, and Qin Xuewen was rewarded as the third class reward of Medical Achievement by Fuwai Hospital in 2001-2002 (2003).

10.       Evaluation of clinical efficacy of coronary arterial intervention therapy by Chen Jilin, Gao Runlin, Yang Yuejin, Qiao Shubing, and Qin Xuewen was rewarded as the first class reward of Medical Achievement by Fuwai Hospital in 2001-2002 (2003).

11.       The comparative study of apical biplane 2DE with LVG in determining LVVs and LVEF in patients with CHD was rewarded as the first class reward of excellent wall thesis by Chinese Medical Association (2004).

12.       In 2003, the book of Coronary Disease won two rewards, nomination of the 6th National Book Reward and the first class reward of the 11st National Outstanding Technical Book (2004).

13.       Collateral Disease Theory and its Applications won Hebei Science and Technology Advancement award, rank 1 (2005).

14.       Using Stent-Graft and Taxus stent for post CABG long LAD lesions with aneurysm won “Medical center Web 2,004 annual cases of outstanding” , rank 2(2005).

15.       The evaluation and promotion of the Clinical efficacy of Coronary Intervention won Beijing Municipal Science and Technology Advancement Award, rank 2(2006).

Articles and Other Publications

He has published more than 200 academic articles.

1.          Yang YJ, et al. Quantitive assessment of regional wall motion abnormalities with 2Dein cases of myocardial infarction. Chn Med Sci J 1992; 7(2):108-111.

2.          Yang YJ, et al. Quantitive analysis of regional wall motion with two-dimensional echocardiogrphy - The selection of reference axis system.The 2 nd Interational Symposium on CAD and Hypertension Abstracts p45,Oct 28-30,1993,Beijing,P.R.China.

3.          Yang YJ, et al. The beneficial effects of NTG on left ventricular volumes and systolic function in patients with myocardial infarction. Chin Med J 1995; 108 (3): 188-193.

4.          Yang YJ, et al. The beneficial effects of low-dose NTG infusion on LVV and systolic function in MI(abstracts).The 11th Asian-Pacific Congress of Cardiology (APCC)abstracts.1995 P5-38; sept.17-22. 1995; Bali£¬Indonesia.

5.          Yang YJ, et al. Quantitative analysis of regional wall motion with apical biplan 2DE-echocardiography--The selection of reference axis system. J Chin Assoc. Ultras Med Eng.1996; 2(1): 42-46.

6.          Yang YJ, et al. Beneficial effects of early coronary reperfusion on LV remodeling and systolic function in patients with AMI. Chin Med J 1998; 111(2): 142-146.

7.          Yang YJ, et al. Nitrate echocardiography and combined low dose dobutamine-nitrate echocardiography to identify hibernating myocardium.JACC.1998; 31(5) Supple -C: 46C.

8.          Yang YJ, et al. Combined Low Dose Dobutamine-Nitrate Echocardiography in Comparison of Dobutamine Alone for Identifying Viable Myocardium. JACC 2000; 35(2) Suppple-A: 487A.

9.          Yang YJ, et al. Comparative effects of losartan, enalapril and their combination in preventing left ventricular remodeling after acute myocardial infarction in rats. Journal of the Renin-Angiotensin-Aldosterone System, 20001(1)78.

10.       Yang YJ, et al. Comparison of losartan, enalapril and their combination in preventing ventricular remodeling after myocardial infarction in rats. Eur Heart J 2000; 21(Suppl):72.

11.       Yang YJ, et al. Comparison of Low, Middle and High Doses of Carvedilol and Metoprolol in Preventing from Post Infarction Ventricular Remodeling in Rats.Heart Disease—New Trends in Research, Diagnosis and Treatment(USA) MEDIMOND MEDICAL PUBLICATIONS, Copyright 2001; 281290.

12.       Yang YJ, et al. Comparative Effects of Losartan, Carvedilol and Their Combination in Preventing From Left Ventricular Remodeling After Acute Myocardial Infarction In Rats. Heart Disease—New Trends in Research, Diagnosis and Treatment(USA) MEDIMOND MEDICAL PUBLICATIONS, Copyright 2001291300.

13.       Yang YJ, et al. Comparative Effects of Cilazapril, Carvedilol and their combination in Preventing from Left Ventricular Remodeling After Acute Myocardial Infarction In Rats. Heart Disease—New Trends in Research, Diagnosis and Treatment(USA) MEDIMOND MEDICAL PUBLICATIONS, Copyright 2001301310.

14.       Yang YJ, et al. Comparative effects of losartan, carvedilol and their combination in preventing left ventricular remodeling after acute myocardial infarction in rats. Journal of the Renin-Angiotensin-Aldosterone System, 2001;2(1): 79 (abstract)

15.       Yang YJ, et al. Comparative effects of cilazapril, carvedilol and their combination in preventing left ventricular remodeling after acute myocardial infarction in rats. Journal of the Renin-Angiotensin-Aldosterone System 2001;2(1): 81 (abstract)

16.       Yang YJ, et al. Comparative effects of cilazapril, carvedilol and their combination in preventiong from left ventricular remodeling after acute myocardial infarction in rats.Journal of the Renin-Angiotensin-Aldosterone System,2002;3:31-35.

17.       Yang YJ, et al.Comparative effects of carvedilol and losartan alone and in combination for preventing left ventricular remodeling after acute myocardial infarction in rats. Circulation Journal, 2003;67(2):159-162.

18.       Yang YJ, et al. Comparison of metoprolol with low, middle and high dose of carvedilol in prevention of postinfarction left ventricular remodeling in rats. Japanese Heart Journal, 2003; 44: 978-988.

19.       Yang YJ, et al. Different effect of Tirofiban and aspirin plus Clopidogrel on myocardial no-reflow in a mini-swine model of acute myocardial infarction and reperfusion. Heart 2006; 92: 1131-1137.

20.       Yang YJ, et al. Post-infarction treatment with simvastatin reduces myocardial no-reflow by opening of the KATP channel. Eur J Heart Fail 2007; 9: 30-36

21.       Zhao JL, Yang YJ. Pretreatment with simvastatin reduces myocardial no-reflow by opening mitochondrial K(ATP) channel. Br J Pharmacol 2006; 149: 243-249.

22.       Zhao JL, Yang YJ.Pretreatment with fosinopril or valsartan reduces myocardial no-reflow after acute myocardial infarction and reperfusion. Coron Artery Dis 2006; 17: 463-469.

23.       Zhao JL, Yang YJ Carvedilol preserves endothelial junctions and reduces myocardial no-reflow after acute myocardial infarction and reperfusion. Int J Cardiol 2007; 115: 34-341.

24.       Zhao JL, Yang YJ Nicorandil reduces myocardial no-reflow by protection of endothelial function via the activation of K(ATP) channel. Clin Chim Acta 2006; 374: 100-105.

25.       Zhao JL, Yang YJ Different effects of adenosine and calcium channel blockade on myocardial no-reflow after acute myocardial infarction and reperfusion. Cardiovasc Drugs Ther 2006; 20(3):167-175.

26.       Zhao JL, Yang YJ, et al. Different effects of postconditioning on myocardial no-reflow in the normal and hypercholesterolemic mini-swines. Micreovasc Res 2007; 73: 137-142.

27.       Zhao JL, Yang YJ, et al. Effects of statins on contrast-induced nephropathy in patients with acute myocardial infarction treated with primary angioplasty. Int J Cardiol 2007; Apr 24 [Epub ahead of print].

28.       Zhao JL, Yang YJ, et al. Intravenous nicorandil preserves endothelial junctions by decreasing endothelin-1 via activation of ATP-sensitive K+ channel. Vasa 2007; 6: 175-179.

29.       Zhao JL, Yang YJ, et al. Effects of statin therapy on reperfusion arrhythmia in patients who underwent successful primary angioplasty. Clin Res Cardiol 2008; 97: 147-151.

30.       Qian HY, Yang YJ, et al. Cellular cardiomyoplasty by catheter-based infusion of stem cells in clinical settings. Transplant Immunology 2006, 16(3-4) :135-147.

31.       Qian HY, Yang YJ, et al. Intracoronary delivery of autologous bone marrow mononuclear cells radiolabeled by 18F-fluoro-deoxy-glucose: early distribution and the effects on post-infarct hearts of swine models. Journal of Cellular Biochemistry 2007; 102(1): 64-74.

32.       Qian HY, Yang YJ, et al. The role of vascular stem cells in atherogenesis and post-angioplasty restenosis. Ageing Res Rev 2007; 102(1): 64-74.

33.       Qian HY, Yang YJ, et al. Effects of Tongxinluo-facilitated cellular cardiomyoplasty with autologous   bone marrow-mesenchymal stem cells on post-infarct swine hearts. Chinese Medical Journal 2007; 120(16):1416-1425.

34.       Yang YJ, et al.  Atorvastatin treatment improved post-infarction microenvironments to facilitate the survivals and activities of implanted mesenchymal stem cells in swine hearts with acute myocardial infarction and reperfusion.European Heart Journal[2008] 29, 1578-1590, IF 7.3Yang YJ, et al.  Spontaneous and induced cardiomyocyte differentiation of porcine bone marrow-derived mesenchymal stem cells is heterogeneous in vitro.submitted to Cardiovasc Res

35.       Yang YJ, Kandzari DE, Gao Z, , et al.Transradial Versus Transfemoral Method of Percutaneous Coronary Revascularization for Unprotected Left Main Coronary Artery Disease: Comparison of Procedural and Late-Term Outcomes . JACC Cardiovasc Interv. 2010 Oct;3(10):1035-42.

36.       Li XD, Yang YJ, Geng YJ, et al.Tongxinluo Reduces Myocardial No-Reflow and Ischemia-Reperfusion Injury by Stimulating the Phosphorylation of eNOS via the PKA Pathway. Am J Physiol Heart Circ Physiol 299: H1255-H1261, 2010. IF: 3.7

Correspondence

1. Sun Y, Yang Y, Pei W, Wu Y, Zhao J.Is elevated high-density lipoprotein cholesterol always good for coronary heart disease? Clin Cardiol. 2007 Nov;30(11):576-80.

2. Pei WD, Zhang YH, Sun YH, Gu YC, Wang YF, Zhang CY, Zhang J, Liu LS, Hui RT, Liu YQ, Yang YJ.

Apolipoprotein E polymorphism influences lipid phenotypes in Chinese families with familial combined hyperlipidemia. Circ J. 2006 Dec;70(12):1606-10.

3. Sun YH, Yang YJ, Pei WD, Wu YJ, Gao RL. Patients with low high-density lipoprotein-cholesterol or smoking are more likely to develop myocardial infarction among subjects with a visible lesion or stenosis in coronary artery. Circ J. 2006 Dec;70(12):1602-5.

4. Pei WD, Sun YH, Lu B, Liu Q, Zhang CY, Zhang J, Jia YH, Lu ZL, Hui RT, Liu LS, Yang YJ. Apolipoprotein B is associated with metabolic syndrome in Chinese families with familial combined hyperlipidemia, familial hypertriglyceridemia and familial hypercholesterolemia. Int J Cardiol. 2007 Mar 20;116(2):194-200.

5. Pei WD, Sun YH, Liu Q, Zheng WY, Zhang J, Zhang CY, Gong J, Hopkins PN, Hui RT, Liu LS, Yang YJ.

Associations of apolipoprotein B with pulse pressure and glucose in Chinese families with familial combined hyperlipidemia. Int J Cardiol. 2007 Feb 14;115(3):293-6. Epub 2006 Jun 22.

6. Sun YH, Pei WD, Wu YJ, Ye SD, Wang GG, Gao RL, Yang YJ. [Chlamydia pneumoniae infection increases the risk of coronary artery disease in the patients with dyslipidemia] Zhonghua Yi Xue Za Zhi. 2004 Dec 2;84(23):1990-3. Chinese.

7.Sun Y, Pei W, Welte T, Wu Y, Ye S, Yang Y. Cytomegalovirus infection is associated with elevated interleukin-10 in coronary artery disease. Atherosclerosis. 2005 Mar;179(1):133-7. Epub 2004 Nov 11.

8.Sun Y, Pei W, Wu Y, Yang Y.An association of herpes simplex virus type 1 infection with type 2 diabetes.  Diabetes Care. 2005 Feb;28(2):435-6. No abstract available.