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Gil F Salles

 Gil F Salles, MD, PhD, Professor, Department of Internal Medicine, Medical School, Federal University of Rio de Janeiro, 21941-901 Rio de Janeiro, RJ, Brazil.

Past Positions

1984-1992          Physician, Division of Internal Medicine, Health Ministry Hospital.

1987-1995          Instructor, Department of Internal Medicine, Medical School, Federal University of Rio de Janeiro.

1992-2010          Professor of Internal Medicine, Department of Internal Medicine, Medical School, Federal University of Rio de Janeiro.

1992-1994 and 2002-2004 Coordinator, Residency Program in Internal Medicine, University Hospital, Federal University of Rio de Janeiro.

1994-1996          Coordinator, Internal Medicine Under-graduation Training, Department of Internal Medicine, Medical School, Federal University of Rio de Janeiro.

1996-2000          Chief, Internal Medicine Service, University Hospital, Federal University of Rio de Janeiro.

2003-2010          Vice-Chief, Internal Medicine Service, University Hospital, Federal University of Rio de Janeiro.

2004-2006          Coordinator of Under-graduation students, Department of Internal Medicine, Medical School, Federal University of Rio de Janeiro

2006-2010          Vice-Chief, Department of Internal Medicine, Medical School, Federal University of Rio de Janeiro.

Present Positions

1987- Physician, Division of Internal Medicine, University Hospital, Federal University of Rio de Janeiro.

2000- Scientific Director, Brazilian Society of Internal Medicine.

2003- Member, University Council for Under-graduated Students, Federal University of Rio de Janeiro.

2004- Professor of the Post-Graduate Internal Medicine Program, Medical School, Federal University of Rio de Janeiro.

2006- Researcher 1, Brazilian Research Council (CNPq).

2010- Chief, Internal Medicine Department, Medical School, Federal University of Rio de Janeiro.

2011- Full Professor of Internal Medicine, Department of Internal Medicine, Medical School, Federal University of Rio de Janeiro.

Selected Peer-Reviewed Publications

1- Cardoso C, Salles G, Bloch K, Deccache W, Siqueira–Filho AG. Clinical determinants of increased QT dispersion in patients with diabetes mellitus. Int J Cardiol 2001;79:253-262.

2- Cardoso C, Salles G. Ventricular repolarization in diabetes mellitus: still much to learn. Clin Auton Res 2002;12:346-348.

3- Cardoso C, Salles G, Decacche W. Prognostic value of QT interval parameters in type 2 diabetes mellitus – results of a long-term follow-up prospective study. J Diabetes Complications 2003;17:169-178.

4- Cardoso CRL, Salles G, Deccache W. QTc interval is a predictor of future stroke in type 2 diabetes mellitus. Stroke 2003;34:2187-2194.

5- Salles G, Xavier SS, Sousa AS, Hasslocher-Moreno A, Cardoso CRL. Prognostic value of QT interval parameters for mortality risk stratification in Chagas’disease: results of a long-term follow-up study. Circulation 2003;108:305-312.

 6- Salles G, Cardoso CRL, Decacche W. Multivariate associates of QT interval parameters in diabetic patients with arterial hypertension: importance of left ventricular mass and geometric patterns. J Hum Hypertens 2003;17:561-567.

7- Salles G, Cardoso C, Xavier S, Sousa A, Hasslocher-Moreno A. Electrocardiographic ventricular repolarization parameters in chronic Chagas’disease as predictors of asymptomatic left ventricular systolic dysfunction. PACE 2003;26:1326-1335.

8- Muxfeldt E, Bloch K, Nogueira A, Salles GF. Twenty-four hour ambulatory blood pressure monitoring pattern of resistant hypertension. Blood Press Monit 2003;8:181-185.

9- Bloch KV, Salles GF, Muxfeldt E, Nogueira A. Orlistat in Hypertensive Overweight/Obese Patients: Results of a Randomized Clinical Trial. J Hypertens 2003;21:2159-2165.

10- Salles GF, Bloch K, Cardoso C. Mortality and predictors of mortality in a cohort of Brazilian type 2 diabetic patients. Diabetes Care 2004; 27:1299-1305.

11- Salles G, Xavier S, Sousa A, Hasslocher–Moreno A, Cardoso C. T-wave axis deviation as an independent predictor of mortality in chronic Chagas’ disease. Am J Cardiol 2004;93:1136-1140

12- Cardoso C, Salles G. QT-interval parameters in end-stage renal disease – Is cardiovascular autonomic neuropathy unimportant? Clin Auton Res 2004;14:214-217.

13- Muxfeldt E, Salles GF, Bloch K, Nogueira A. Demographic and clinical characteristics of hypertensive patients in the internal medicine outpatient clinic of an University hospital in Rio de Janeiro. São Paulo Med J. 2004;122:87-93.

14- Salles GF, Deccache W, Cardoso C. Usefulness of QT-interval parameters for cardiovascular risk stratification in type 2 diabetic patients with arterial hypertension. J Hum Hypertens 2005;19:241-249.

15- Cardoso CRL, MAO Sales, Papi JAS, Salles GF. QT–interval parameters are increased in systemic lupus erythemathosus. Lupus 2005; 10:846-852.

16- Muxfeldt ES, Bloch KV, Nogueira AR, Salles GF. True resistant hypertension: Is it possible to be recognized in the office? Am J Hypertens 2005;18:1534-1540.

17- Salles GF, Leocadio S, Bloch K, Nogueira AR, Muxfeldt E. Combined QT interval and voltage criteria improve left ventricular hypertrophy detection in resistant hypertension. Hypertension 2005;46:1207-1212

18- Salles G, Cardoso C, Nogueira AR, Bloch K, Muxfeldt E. Importance of the electrocardiographic strain pattern in patients with resistant hypertension. Hypertension 2006; 48:437-442.

19- Nogueira AD, Fernandes AS, Coutinho ES, Salles GF, Muxfeldt ES, Bloch KV. Factors associated with microalbuminuria in resistant hypertension. Int J Cardiol 2007; 121:86-87.

20- Cardoso CRL, Salles GF. Macro and microvascular complications are determinants of increased infection-related mortality in Brazilina type 2  diabetes mellitus patients. Diabetes Res Clin Pract 2007; 75:51-58.

21- Salles GF, Fizman R , Cardoso CRL, Muxfedlt ES. Relation of Left Ventricular Hypertrophy with Systemic Inflammation and Endothelial Damage in Resistant Hypertension. Hypertension 2007; 50:723-728.

22- Salles GF. The Electrocardiographic Strain Pattern and Cardiovascular Prognosis in Hypertension. Am J Hypertens 2007; 20:1005-1006.

23- Salles G, Cardoso C, Leocadio S, Muxfeldt ES. Recent ventricular repolarization markers in resistant hypertension: are they different from the traditional QT-interval? Am J Hypertens 2008; 21:47-53.

24- Cardoso CRL , Salles GF. Predictors of development and progression of microvascular complications in a cohort of Brazilian type 2 diabetic patients. J Diabetes Complications 2008; 22: 164 - 170.

25- Cardoso CRL, Signorelli, Papi JA , Salles GF .Prevalence and factors associated with dyslipoproteinemias in Brazilian Systemic Lupus Erythematosus patients . Rheumatol Int 2008; 28: 323 - 327.

26- Muxfeldt ES, Salles GF. Ambulatory arterial stiffness index or pulse pressure: which one correlates better with arterial stiffness in resistant hypertension?. Hypertens Res 2008; 31: 607 – 613.

27- Muxfeldt ES, Salles GF. Pulse pressure or dipping pattern: which one is a better cardiovascular risk marker in resistant hypertension? J Hypertens 2008; 26:878 - 884.

28- Cardoso C, Leite NC, Freitas L, Dias SB, Muxfeldt ES, Salles GF. Pattern of 24-hour ambulatory blood pressure monitoring in type 2 diabetic patients with cardiovascular dysautonomy. Hypertens Res 2008; 31: 865 - 872.

29- Salles GF, Cardoso CRL, Muxfeldt ES. Prognostic Influence of Office and Ambulatory Blood Pressures in Resistant Hypertension. Arch Intern Med 2008; 168: 2340 – 2346.

30- Cardoso CRL, Signorelli F, Papi JA, Salles GF. Initial and accrued damage as predictors of mortality in Brazilian patients with systemic lupus erythematosus: a cohort study. Lupus (Basingstoke) 2008; 17: 1042 – 1048.

31- Cardoso CRL, Salles GF. Gross proteinuria is a strong risk predictor for cardiovascular mortality in Brazilian type 2 diabetic patients. Brazi J Med Biol Res 2008; 41: 674 – 680.

32- Leite NC, Salles GF, Araujo AL, Villela-Nogueira C, Cardoso C. Prevalence and associated factors of non-alcholic fatty liver disase in patients with type 2 diabetes. Liver Int 2009 29: 113 - 119.

33- Salles GF, Cardoso CRL, Muxfeldt ES. Prognostic value of ventricular repolarization prolongation in resistant hypertension: a prospective cohort study. J Hypertens 2009; 27: 1094 – 1101.

34- Muxfeldt ES, Cardoso CRL, Salles GF. Prognostic Value of Nocturnal Blood Pressure Reduction in Resistant Hypertension. Arch Intern Med 2009; 169: 874 – 880.

35- Cardoso CRL, Ferreira MT, Leite NC, Barros PN, Conte PH, Salles GF. Microvascular degenerative complications are associated with increased aortic stiffness in type 2 diabetic patients. Atherosclerosis 2009; 205: 472 – 476.

36- Castelpoggi CH, Pereira VS, Fiszman R, Cardoso CRL, Muxfeldt ES, Salles GF. A blunted decrease in nocturnal blood pressure is independently associated with increased aortic stiffness in patients with resistant hypertension. Hypertens Res 2009; 32: 591 – 596.

37- de Souza F, Muxfeldt ES, Fiszman R, Salles GF. Efficacy of Spironolactone Therapy in Patients with True Resistant Hypertension. Hypertension (Dallas, Tex. 1979) 2010; 55: 147 – 152.

38- Muxfeldt ES, Cardoso CRL, Dias VB, Nascimento ACM, Salles GF. Prognostic impact of the ambulatory arterial stiffness index in resistant hypertension. J Hypertens 2010; 28: 1547 – 1553.

39- Salles GF, Cardoso CRL, Fiszman R, Muxfeldt ES. Prognostic impact of baseline and serial changes in electrocardiographic left ventricular hypertrophy in resistant hypertension. Am Heart J 2010: 159: 833 – 840.

40- Salles GF, Cardoso CRL, Fiszman R, Muxfeldt ES. Prognostic significance of baseline and serial changes in electrocardiographic strain pattern in resistant hypertension. J Hypertens 2010; 28: 1715 – 1723.

41- Salles GF, Teixeira GB, Leite NC, Muxfeldt ES, Cardoso CRL. Uncontrolled isolated office hypertension is associated with subclinical markers of cardiovascular disease in hypertensive type 2 diabetic patients. Hypertension Res 2010; 33: 819 – 824.

42- Salles GF, Cardoso CRL, Fiszman R, Muxfeldt ES. Prognostic importance of baseline and serial changes in microalbuminuria in patients with resistant hypertension. Atherosclerosis 2011; 216: 199-204.

43- Leite NC, Villela-Nogueira C, Pannain V, Caroli-Bottino A, Rezende G, Cardoso CRL, Salles GF. Histopathological stages of nonalcoholic fatty liver disease in type 2 diabetes: prevalences and correlated factors. Liver Int 2011; 31: 700-706.

44- Cardoso CRL, Maia MDL, Oliveira FP, Leite NC, Salles GF. High fitness is associated with a better cardiovascular risk profile in patients with type 2 diabetes mellitus. Hypertension Res 2011; 34: 856-861.

45- Bulzico DA, Zajdenverg L, Cabizuca CA, Oliveira JEP, Salles GF. Assessment of Arterial Stiffness in Women with Gestational Diabetes. Diabetic Med, 2011 (in press).

46- Salles GF, Cardoso CRL, Pereira VS, Fiszman R, Muxfeldt ES. Prognostic Significance of a Reduced Glomerular Filtration Rate and Interaction with Microalbuminuria in Resistant Hypertension: A Cohort Study. J Hypertension 2011 (in press).

47- Cardoso CRL, Leite NC, Muxfeldt ES, Salles GF. Thresholds of Ambulatory Blood Pressure Associated to the Presence of Chronic Complications in Type 2 Diabetes. Am J Hypertens, 2011 (in press).

Experience and Research Interests

Arterial Hypertension, particularly clinical studies on resistant hypertension, ambulatory blood pressure monitoring, left ventricular hypertrophy, microalbuminuria, arterial stiffness and cardiovascular risk factors.

Type 2 Diabetes, particularly clinical studies on cardiovascular diseases and their prognostic factors, microvascular complications, ambulatory blood pressure monitoring, arterial stiffness and non-alcoholic fatty liver disease.