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Sawa Kostin

Date of birth: 21.01.1961

Place of birth: Vorniceni, Republic of Moldova

Nationality: Germany

Level in international classification: Highest scientific category

Address: Ludwigstrasse 43/FGI, 61231 Bad Nauheim, Germany

Academic achievements

Studies in Medicine and registration as Physician, University of Medicine, Chisinau, Republic of Moldova (1978-1984). Diploma with Distinction.

Doctoral Thesis, Instiute of Human Pathology, Moscow, Russia (1990).

Thesis for obtaining the degree of “Doctor of Science“, Institute of Cardiology, Kishinev, Moldova (1994).

Awarding the title of “Research Associate Professor“, Institute of Cardiology, Republic of Moldova (1994).

Postdoctoral Research Fellow from the European Society of Cardiology, Max-Planck-Istitute, Bad Nauheim, Germany (1996-1997).

Postdoctoral Research Fellow from the German Society of Cardiology, Max-Planck-Istitute, Bad Nauheim, Germany (1997-1999).

Postdoctoral Research Fellow from the Max-Planck Society, Max-Planck-Istitute, Bad Nauheim, Germany (2000-2002).

Research Associate, Max-Planck-Istitute, Bad Nauheim, Germany (2002-2004).

Thesis for obtaining the degree of „Doctor of Phylosophy“, University of Gießen, Germany (2005). Diploma with Distinction.

Awarding the title of „Associate Professor“, University of Gießen, Germany (2005).

Group Leader, Max-Planck-Istitute for Heart and Lung Research, Bad Nauheim, Germany (2005-present).

Thesis for obtaining the degree of „Doctor Habilitatus“ of Medicine, University of Gießen, Germany (2008).

Awarding the title of “Privat-Dozent“, University of Gießen, Germany (2008).

Awarding the title of “Professor in Medicine and Pathology“, University of Gießen, Germany (2009).

Awarding the title of “Professor in Medicine“, University of Medicine and Pharmacy, Romania (2010).

Awarding the title of “Professor in Medicine“, University of Medicine and Pharmacy “N.Testemitanu“, Chisinau, Republic of Moldova (2010).

Scientific awards

Young Investigator Award, XIV World Congress of the International Society for Heart Research, Winnipeg, Canada, 2002.

Award for the best data presented at the “TUNEL SCIENCE“, World EXPO 2002, Hannover, Germany (2002).

Fritz-Acker Award of the German Society of Cardiology (2009).

Honory Member of the Romanian Academy of Science (2009).

Honory Member of the Moldavian Academy of Science (2010).

Member of the „Marquis Who’s Who“ Publications Board (USA, 2011).

Professional activities

Clinical Internship in Cardiology and Board Certification, Institute of Cardiology, Moscow, Russia (1984-1989).

Clinical Internship in Pathology and Board Certification, Institute of Human Pathology, Moscow, Russia (1989-1993).

Group Leader of the laboratory, “Myocarditis and Cardiomyopathies“, Institute of Cardiology, Chisinau, Republic of Moldova (1993-1995).

Postdoctoral Research Fellow of the European Society of Cardiology, Max-Planck-Istitute, Bad Nauheim, Germany (1996-1997).

Postdoctoral Research Fellow of the German Society of Cardiology, Max-Planck-Istitute, Bad Nauheim, Germany (1997-1999).

Postdoctoral Research Fellow of the Max-Planck Society, Max-Planck-Istitute, Bad Nauheim, Germany (2000-2002).

Research Associate, Max-Planck-Istitute, Bad Nauheim, Germany (2002-2004).

Group Leader, Max-Planck-Istitute for Heart and Lung Research, Bad Nauheim, Germany (2005-2007).

Chief of Department "Molecular and Structural Biology", Max-Planck-Istitute for Heart and Lung Research (W. G. Kerckhof Institute) and Kerckhoff Clinic, Bad Nauheim, Germany (2007-present).

Member of Editorial Board

Journal of Cellular and Molecular Medicine

 Current Cardiology Review

World Journal of Experimantal Medicine

Reviewer

Cardiovascular Research (65 papers reviewed)

Journal of Cellular and Molecular Medicine (57 papers reviewed)

Journal of American College of Cardiology (22 papers reviewed)

Other journals (32 papers reviewed)

List of Publications

1.     Kostin S. Types of cardiomyocyte death and clinical outcomes in patients with heart failure. Journal of the American College of Cardiology. 2011;57(14):1532-1534.

2.     Polyakova V, Loeffler I, Hein S, Miyagawa S, Piotrowska I, Dammer S, Risteli J, Schaper J, Kostin S. Fibrosis in endstage human heart failure: Severe changes in collagen metabolism and MMP/TIMP profiles. International journal of cardiology. 2011;151(1):18-33.

3.     Mollmann H, Nef HM, Voss S, Troidl C, Willmer M, Szardien S, Rolf A, Klement M, Voswinckel R, Kostin S, Ghofrani HA, Hamm CW, Elsasser A. Stem cell-mediated natural tissue engineering. Journal of cellular and molecular medicine. 2011;15(1):52-62.

4.    Miyagawa S, Roth M, Saito A, Sawa Y, Kostin S. Tissue-engineered cardiac constructs for cardiac repair. The Annals of thoracic surgery. 2011;91(1):320-329.

5.     Kumar S, Flacke JP, Kostin S, Appukuttan A, Reusch HP, Ladilov Y. SLC4A7 sodium bicarbonate co-transporter controls mitochondrial apoptosis in ischaemic coronary endothelial cells. Cardiovascular research. 2011;89(2):392-400.

6.     Knoll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schafer K, Knoll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didie M, Quentin T, Maier LS, Teucher N, Unsold B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJ, Sattler M, Wilmanns M, Chien KR. Telethonin Deficiency Is Associated With Maladaptation to Biomechanical Stress in the Mammalian Heart. Circulation research. 2011.

7.     Abassi ZA, Barac YD, Kostin S, Roguin A, Ovcharenko E, Awad H, Blank A, Bar-Am O, Amit T, Schaper J, Youdim M, Binah O. TVP1022 Attenuates Cardiac Remodeling and Kidney Dysfunction in Experimental Volume Overload-Induced Congestive Heart Failure. Circulation. Heart failure. 2011;4(4):463-473.

8.     Troidl C, Nef H, Voss S, Schilp A, Kostin S, Troidl K, Szardien S, Rolf A, Schmitz-Rixen T, Schaper W, Hamm CW, Elsasser A, Mollmann H. Calcium-dependent signalling is essential during collateral growth in the pig hind limb-ischemia model. Journal of molecular and cellular cardiology. 2010;49(1):142-151.

9.     Popescu LM, Manole CG, Gherghiceanu M, Ardelean A, Nicolescu MI, Hinescu ME, Kostin S. Telocytes in human epicardium. Journal of cellular and molecular medicine. 2010;14(8):2085-2093.

10.   Mollmann H, Nef HM, Kostin S, Dragu A, Maack C, Weber M, Troidl C, Rolf A, Elsasser A, Bohm M, Brantner R, Hamm CW, Holubarsch CJ. Ischemia triggers BNP expression in the human myocardium independent from mechanical stress. International journal of cardiology. 2010;143(3):289-297.

11.   Mandache E, Gherghiceanu M, Macarie C, Kostin S, Popescu LM. Telocytes in human isolated atrial amyloidosis: ultrastructural remodelling. Journal of cellular and molecular medicine. 2010;14(12):2739-2747.

12.   Kostin S. Myocardial telocytes: a specific new cellular entity. Journal of cellular and molecular medicine. 2010;14(7):1917-1921.

13.   Knoll R, Kostin S, Klede S, Savvatis K, Klinge L, Stehle I, Gunkel S, Kotter S, Babicz K, Sohns M, Miocic S, Didie M, Knoll G, Zimmermann WH, Thelen P, Bickeboller H, Maier LS, Schaper W, Schaper J, Kraft T, Tschope C, Linke WA, Chien KR. A common MLP (muscle LIM protein) variant is associated with cardiomyopathy. Circulation research. 2010;106(4):695-704.

14.   Kallenbach K, Sorrentino S, Mertsching H, Kostin S, Pethig K, Haverich Md A, Cebotari S. A novel small animal model for accelerated investigation of tissue engineered aortic valved conduits. Tissue Eng Part C Methods. 2010;16(1):41-50.

15.   Ivanova VM, Kostin SI, Popovich IM, Chebanu NV, Kobets VA, Popovich MI. [Qualitative and quantitative changes of circulating in blood endotheliocyte precursor cells in patients with hypercholesterolemia]. Kardiologiia. 2010;50(12):27-31.

16.   Groger N, Frohlich H, Maier H, Olbrich A, Kostin S, Braun T, Boettger T. SLC4A11 prevents osmotic imbalance leading to corneal endothelial dystrophy, deafness, and polyuria. The Journal of biological chemistry. 2010;285(19):14467-14474.

17.   Dimomeletis I, Deindl E, Zaruba M, Groebner M, Zahler S, Laslo SM, David R, Kostin S, Deutsch MA, Assmann G, Mueller-Hoecker J, Feuring-Buske M, Franz WM. Assessment of human MAPCs for stem cell transplantation and cardiac regeneration after myocardial infarction in SCID mice. Experimental hematology. 2010;38(11):1105-1114.

18.   Voss S, Möllmann H, Nef H, Kostin S, Troidl C, Lintz M, Szardien S, Sprenzel J, Skwara V, Rolf A, Hamm C, Elsässer A. Desynchronization: a novel model to induce heart failure. Thorac Cardiovasc Surg. 2009;57:441-448.

19.   Tudorache I, Kostin S, Meyer T, Teebken O, Bara C, Hilfiker A, Haverich A, Cebotari S. Viable vascularized autologous patch for transmural myocardial reconstruction. Eur J Cardiothorac Surg. 2009;36(2):306-311; discussion 311.

20.   Troidl C, Troidl K, Schierling W, Cai WJ, Nef H, Mollmann H, Kostin S, Hammer L, Elsasser A, Schmitz-Rixen T, Schaper W. Trpv4 induces collateral vessel growth during regeneration of the arterial circulation. Journal of cellular and molecular medicine. 2009;13(8b):2613-2626-2621.

21.   Troidl C, Mollmann H, Nef H, Masseli F, Voss S, Szardien S, Willmer M, Rolf A, Rixe J, Troidl K, Kostin S, Hamm C, Elsasser A. Classically and alternatively activated macrophages contribute to tissue remodelling after myocardial infarction. Journal of cellular and molecular medicine. 2009:DOI: JCMM707 [pii]710.1111/j.1582-4934.2009.00707.x.

22.   Reisner Y, Meiry G, Zeevi-Levin N, Barac DY, Reiter I, Abassi Z, Ziv N, Kostin S, Schaper J, Rosen MR, Binah O. Impulse conduction and gap junctional remodelling by endothelin-1 in cultured neonatal rat ventricular myocytes. Journal of cellular and molecular medicine. 2009;13(3):562-573.

23.   Nef HM, Mollmann H, Troidl C, Kostin S, Voss S, Hilpert P, Behrens CB, Rolf A, Rixe J, Weber M, Hamm CW, Elsasser A. Abnormalities in intracellular Ca2+ regulation contribute to the pathomechanism of Tako-Tsubo cardiomyopathy. Eur Heart J. 2009;30(17):2155-2164.

24.   Mollmann H, Nef HM, Voss S, Troidl C, Willmer M, Szardien S, Rolf A, Klement M, Voswinckel R, Kostin S, Ghofrani HA, Hamm CW, Elsasser A. Stem cell-mediated natural tissue engineering. Journal of cellular and molecular medicine. 2009.

25.   Mollmann H, Nef HM, Kostin S, Dragu A, Maack C, Weber M, Troidl C, Rolf A, Elsasser A, Bohm M, Brantner R, Hamm CW, Holubarsch CJ. Ischemia triggers BNP expression in the human myocardium independent from mechanical stress. International journal of cardiology. 2009.

26.   Kumar S, Kostin S, Flacke JP, Reusch HP, Ladilov Y. Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells. The Journal of biological chemistry. 2009;284(22):14760-14768.

27.   Kostin S, Popescu LM. A distinct type of cell in myocardium: interstitial Cajal-like cells (ICLCs). Journal of cellular and molecular medicine. 2009;13(2):295-308.

28.   Hein S, Block T, Zimmermann R, Kostin S, Scheffold T, Kubin T, Klövekorn W-P, Schaper J. Deposition of nonsarcomeric alpha-actinin in cardiomyocytes from patients with dilated cardiomyopathy or chronic pressure overload. Exp Clin Cardiol. 2009;14:e68-e75.

29.   Flacke JP, Kumar S, Kostin S, Reusch HP, Ladilov Y. Acidic preconditioning protects endothelial cells against apoptosis through p38- and Akt-dependent Bcl-xL overexpression. Apoptosis. 2009;14(1):90-96.

30.   Boettger T, Beetz N, Kostin S, Schneider J, Kruger M, Hein L, Braun T. Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. J Clin Invest. 2009;119(9):2634-2647.

31.   Vakhrusheva O, Smolka C, Gajawada P, Kostin S, Boettger T, Kubin T, Braun T, Bober E. Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circulation research. 2008;102(6):703-710.

32.   Polyakova V, Miyagawa S, Szalay Z, Risteli J, Kostin S. Atrial extracellular matrix remodelling in patients with atrial fibrillation. Journal of cellular and molecular medicine. 2008;12(1):189-208.

33.   Nef HM, Mollmann H, Troidl C, Kostin S, Bottger T, Voss S, Hilpert P, Krause N, Weber M, Rolf A, Dill T, Schaper J, Hamm CW, Elsasser A. Expression profiling of cardiac genes in Tako-Tsubo cardiomyopathy: insight into a new cardiac entity. Journal of molecular and cellular cardiology. 2008;44(2):395-404.

34.   Nef HM, Mollmann H, Hilpert P, Masseli F, Kostin S, Troidl C, Rolf A, Dill T, Weber M, Hamm C, Elsasser A. Sympathoadrenergic overstimulation in Tako-Tsubo cardiomyopathy triggered by physical and emotional stress. International journal of cardiology. 2008;130(2):266-268.

35.   Mollmann H, Nef HM, Kahlert P, Kostin S, Mollmann S, Weber M, Troidl C, Hamm CW, Holubarsch CJ, Elsasser A. Negative inotropic effect of rapamycin on isolated human cardiomyocytes. J Int Med Res. 2008;36(4):810-814.

36.   Hein S, Kostin S, Schaper J. mRNA cargo no longer on time. Am J Physiol Heart Circ Physiol. 2008;294(3):H1130-1132.

37.   Belema-Bedada F, Uchida S, Martire A, Kostin S, Braun T. Efficient homing of multipotent adult mesenchymal stem cells depends on FROUNT-mediated clustering of CCR2. Cell Stem Cell. 2008;2(6):566-575.

38.   Barac DY, Reisner Y, Silberman M, Zeevi-Levin N, Danon A, Salomon O, Shoham M, Shilkrut M, Kostin S, Schaper J, Binah O. Mechanical load induced by glass microspheres releases angiogenic factors from neonatal rat ventricular myocytes cultures and causes arrhythmias. Journal of cellular and molecular medicine. 2008;12(5B):2037-2051.

39.   Schneider M, Kostin S, Strom CC, Aplin M, Lyngbaek S, Theilade J, Grigorian M, Andersen CB, Lukanidin E, Lerche Hansen J, Sheikh SP. S100A4 is upregulated in injured myocardium and promotes growth and survival of cardiac myocytes. Cardiovascular research. 2007;75(1):40-50.

40.   Nef HM, Mollmann H, Kostin S, Troidl C, Voss S, Weber M, Dill T, Rolf A, Brandt R, Hamm CW, Elsasser A. Tako-Tsubo cardiomyopathy: intraindividual structural analysis in the acute phase and after functional recovery. Eur Heart J. 2007;28(20):2456-2464.

41.   Mees B, Wagner S, Ninci E, Tribulova S, Martin S, van Haperen R, Kostin S, Heil M, de Crom R, Schaper W. Endothelial nitric oxide synthase activity is essential for vasodilation during blood flow recovery but not for arteriogenesis. Arterioscler Thromb Vasc Biol. 2007;27(9):1926-1933.

42.   Kumar S, Kasseckert S, Kostin S, Abdallah Y, Schafer C, Kaminski A, Reusch HP, Piper HM, Steinhoff G, Ladilov Y. Ischemic acidosis causes apoptosis in coronary endothelial cells through activation of caspase-12. Cardiovascular research. 2007;73(1):172-180.

43.   Kumar S, Kasseckert S, Kostin S, Abdallah Y, Piper HM, Steinhoff G, Reusch HP, Ladilov Y. Importance of bicarbonate transport for ischaemia-induced apoptosis of coronary endothelial cells. Journal of cellular and molecular medicine. 2007;11(4):798-809.

44.   Kostin S. Zonula occludens-1 and connexin 43 expression in the failing human heart. Journal of cellular and molecular medicine. 2007;11(4):892-895.

45.   Fischer S, Gerriets T, Wessels C, Walberer M, Kostin S, Stolz E, Zheleva K, Hocke A, Hippenstiel S, Preissner KT. Extracellular RNA mediates endothelial-cell permeability via vascular endothelial growth factor. Blood. 2007;110(7):2457-2465.

46.   Ebelt H, Jungblut M, Zhang Y, Kubin T, Kostin S, Technau A, Oustanina S, Niebrugge S, Lehmann J, Werdan K, Braun T. Cellular cardiomyoplasty: improvement of left ventricular function correlates with the release of cardioactive cytokines. Stem Cells. 2007;25(1):236-244.

47.   Nef HM, Mollmann H, Skwara W, Bolck B, Schwinger RH, Hamm C, Kostin S, Schaper J, Elsasser A. Reduced sarcoplasmic reticulum Ca2+ -ATPase activity and dephosphorylated phospholamban contribute to contractile dysfunction in human hibernating myocardium. Mol Cell Biochem. 2006;282(1-2):53-63.

48.   Mollmann H, Nef HM, Kostin S, von Kalle C, Pilz I, Weber M, Schaper J, Hamm CW, Elsasser A. Bone marrow-derived cells contribute to infarct remodelling. Cardiovascular research. 2006;71(4):661-671.

49.   Mollmann H, Nef HM, Kostin S, Skwara W, Schaper J, Hamm CW, Elsasser A. Images in cardiovascular medicine. Natural tissue engineering inside a ventricular septum defect occluder. Circulation. 2006;113(16):e718-719.

50.   Möllmann H, Nef H, Kostin S, Skwara W, Schaper J, Hamm CW, Elsässer A. Natural tissue engineering inside a ventricular septum defect occluder. Circulation. 2006;113:718-719.

51.   Hein S, Kostin S, Schaper J. Adult rat cardiac myocytes in culture: 'Second-floor' cells and coculture experiments. Exp Clin Cardiol. 2006;11(3):175-182.

52.   Zeevi-Levin N, Barac YD, Reisner Y, Reiter I, Yaniv G, Meiry G, Abassi Z, Kostin S, Schaper J, Rosen MR, Resnick N, Binah O. Gap junctional remodeling by hypoxia in cultured neonatal rat ventricular myocytes. Cardiovascular research. 2005;66(1):64-73.

53.   van Empel VP, Bertrand AT, van der Nagel R, Kostin S, Doevendans PA, Crijns HJ, de Wit E, Sluiter W, Ackerman SL, De Windt LJ. Downregulation of apoptosis-inducing factor in harlequin mutant mice sensitizes the myocardium to oxidative stress-related cell death and pressure overload-induced decompensation. Circulation research. 2005;96(12):e92-e101.

54.   Sharov VG, Kostin S, Todor A, Schaper J, Sabbah HN. Expression of cytoskeletal, linkage and extracellular proteins in failing dog myocardium. Heart Fail Rev. 2005;10(4):297-303.

55.   Schwarz ER, Gupta R, Diep TP, Nowak B, Kostin S, Grohmann B, Uretsky BF, Schaper J. Carvedilol improves myocardial contractility compared with metoprolol in patients with chronic hibernating myocardium after revascularization. J Cardiovasc Pharmacol Ther. 2005;10(3):181-190.

56.   Schaper J, Kostin S. Cell death and adenosine triphosphate: the paradox. Circulation. 2005;112(1):6-8.

57.  Rodriguez M, Cai WJ, Kostin S, Lucchesi BR, Schaper J. Ischemia depletes dystrophin and inhibits protein synthesis in the canine heart: mechanisms of myocardial ischemic injury. Journal of molecular and cellular cardiology. 2005;38(5):723-733.

58.   Kubin T, Tomars M, Fach C, Hein S, Bramlage P, Shim GJ, Scholz D, Kostin S, Zimmermann R, Elsasser A, Schaper W, Schaper J. Transforming growth factor-beta1 downregulates beating frequency and remodeling of cultured rat adult cardiomyocytes. Cell Tissue Res. 2005;321(1):57-66.

59.   Kostin S. Pathways of myocyte death: implications for development of clinical laboratory biomarkers. Adv Clin Chem. 2005;40:37-98.

60.   Ziegelhoeffer T, Fernandez B, Kostin S, Heil M, Voswinckel R, Helisch A, Schaper W. Bone marrow-derived cells do not incorporate into the adult growing vasculature. Circulation research. 2004;94(2):230-238.

61.   Tribulova N, Shneyvays V, Mamedova LK, Moshel S, Zinman T, Shainberg A, Manoach M, Weismann P, Kostin S. Enhanced connexin-43 and alpha-sarcomeric actin expression in cultured heart myocytes exposed to triiodo-L-thyronine. J Mol Histol. 2004;35(5):463-470.

62.   Toyo-Oka T, Kawada T, Nakata J, Xie H, Urabe M, Masui F, Ebisawa T, Tezuka A, Iwasawa K, Nakajima T, Uehara Y, Kumagai H, Kostin S, Schaper J, Nakazawa M, Ozawa K. Translocation and cleavage of myocardial dystrophin as a common pathway to advanced heart failure: a scheme for the progression of cardiac dysfunction. Proc Natl Acad Sci U S A. 2004;101(19):7381-7385.

63.   Polyakova V, Hein S, Kostin S, Ziegelhoeffer T, Schaper J. Matrix metalloproteinases and their tissue inhibitors in pressure-overloaded human myocardium during heart failure progression. Journal of the American College of Cardiology. 2004;44(8):1609-1618.

64.   Kostin S, Dammer S, Hein S, Klovekorn WP, Bauer EP, Schaper J. Connexin 43 expression and distribution in compensated and decompensated cardiac hypertrophy in patients with aortic stenosis. Cardiovascular research. 2004;62(2):426-436.

65.   Kostin S. Types and mechanisms of myocyte cell death in diseased human heart. Cardiovasc J S Afr. 2004;15 (4 Suppl 1):S1.

66.   Elsasser A, Vogt AM, Nef H, Kostin S, Mollmann H, Skwara W, Bode C, Hamm C, Schaper J. Human hibernating myocardium is jeopardized by apoptotic and autophagic cell death. Journal of the American College of Cardiology. 2004;43(12):2191-2199.

67.   Voswinckel R, Ziegelhoeffer T, Heil M, Kostin S, Breier G, Mehling T, Haberberger R, Clauss M, Gaumann A, Schaper W, Seeger W. Circulating vascular progenitor cells do not contribute to compensatory lung growth. Circulation research. 2003;93(4):372-379.

68.   van Royen N, Hoefer I, Buschmann I, Kostin S, Voskuil M, Bode C, Schaper W, Piek JJ. Effects of local MCP-1 protein therapy on the development of the collateral circulation and atherosclerosis in Watanabe hyperlipidemic rabbits. Cardiovascular research. 2003;57(1):178-185.

69.   Renner O, Tsimpas A, Kostin S, Valable S, Petit E, Schaper W, Marti HH. Time- and cell type-specific induction of platelet-derived growth factor receptor-beta during cerebral ischemia. Brain Res Mol Brain Res. 2003;113(1-2):44-51.

70.   Kostin S, Rieger M, Dammer S, Hein S, Richter M, Klovekorn WP, Bauer EP, Schaper J. Gap junction remodeling and altered connexin43 expression in the failing human heart. Mol Cell Biochem. 2003;242(1-2):135-144.

71.   Kostin S, Pool L, Elsasser A, Hein S, Drexler HC, Arnon E, Hayakawa Y, Zimmermann R, Bauer E, Klovekorn WP, Schaper J. Myocytes die by multiple mechanisms in failing human hearts. Circulation research. 2003;92(7):715-724.

72.   Hein S, Arnon E, Kostin S, Schonburg M, Elsasser A, Polyakova V, Bauer EP, Klovekorn WP, Schaper J. Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms. Circulation. 2003;107(7):984-991.

73.   Cai WJ, Koltai S, Kocsis E, Scholz D, Kostin S, Luo X, Schaper W, Schaper J. Remodeling of the adventitia during coronary arteriogenesis. Am J Physiol Heart Circ Physiol. 2003;284(1):H31-40.

74.   Zimmermann WH, Schneiderbanger K, Schubert P, Didie M, Munzel F, Heubach JF, Kostin S, Neuhuber WL, Eschenhagen T. Tissue engineering of a differentiated cardiac muscle construct. Circulation research. 2002;90(2):223-230.

75.   van Royen N, Hoefer I, Buschmann I, Heil M, Kostin S, Deindl E, Vogel S, Korff T, Augustin H, Bode C, Piek JJ, Schaper W. Exogenous application of transforming growth factor beta 1 stimulates arteriogenesis in the peripheral circulation. FASEB J. 2002;16(3):432-434.

76.   Schaper J, Kostin S, Hein S, Elsasser A, Arnon E, Zimmermann R. Structural remodelling in heart failure. Exp Clin Cardiol. 2002;7(2-3):64-68.

77.   Kostin S, Klein G, Szalay Z, Hein S, Bauer EP, Schaper J. Structural correlate of atrial fibrillation in human patients. Cardiovascular research. 2002;54(2):361-379.

78.   Kostin S. Structural determinants of atrial and ventricular conduction. Journal of cellular and molecular medicine. 2002;6(1):108-109.

79.   Hein S, Elsasser A, Kostin S, Zimmermann R, Schaper J. Functional disturbances due to structural remodeling in the failing human heart. Arch Mal Coeur Vaiss. 2002;95(9):815-820.

80.   Heil M, Ziegelhoeffer T, Pipp F, Kostin S, Martin S, Clauss M, Schaper W. Blood monocyte concentration is critical for enhancement of collateral artery growth. Am J Physiol Heart Circ Physiol. 2002;283(6):H2411-2419.

81.   Cebotari S, Mertsching H, Kallenbach K, Kostin S, Repin O, Batrinac A, Kleczka C, Ciubotaru A, Haverich A. Construction of autologous human heart valves based on an acellular allograft matrix. Circulation. 2002;106(12 Suppl 1):I63-I68.

82.   Bieber T, Meissner W, Kostin S, Niemann A, Elsasser HP. Intracellular route and transcriptional competence of polyethylenimine-DNA complexes. J Control Release. 2002;82(2-3):441-454.

83.   Suzuki K, Kostin S, Person V, Elsasser A, Schaper J. Time course of the apoptotic cascade and effects of caspase inhibitors in adult rat ventricular cardiomyocytes. Journal of molecular and cellular cardiology. 2001;33(5):983-994.

84.   Li HY, Kotaka M, Kostin S, Lee SM, Kok LD, Chan KK, Tsui SK, Schaper J, Zimmermann R, Lee CY, Fung KP, Waye MM. Translocation of a human focal adhesion LIM-only protein, FHL2, during myofibrillogenesis and identification of LIM2 as the principal determinants of FHL2 focal adhesion localization. Cell Motil Cytoskeleton. 2001;48(1):11-23.

85.   Kostin S, Schaper J. Tissue-specific patterns of Gap junctions in adult rat atrial and ventricular cardiomyocytes in vivo and in vitro. Circulation research. 2001;88(9):933-939.

86.   Erdogan A, Carlsson J, Grumbrecht S, Kostin S, Schulte B, Schlapp M, Neuzner J, Pitschner HF. Electrochemical potentials during radiofrequency energy delivery: a new method to control catheter ablation of arrhythmias. Europace. 2001;3(3):201-207.

87.   Elsässer A, Kostin S, Hein S, Zimmermann R, Schaper J. Remodeling and cell death in failing human myocardium. In: Lewis BS, Halon DA, Flugelman M, Hradec J, eds. Coronary Artery disease. Praque: Monduzzi - Medimond Inc; 2001:19-24.

88.   Buschmann IR, Hoefer IE, van Royen N, Katzer E, Braun-Dulleaus R, Heil M, Kostin S, Bode C, Schaper W. GM-CSF: a strong arteriogenic factor acting by amplification of monocyte function. Atherosclerosis. 2001;159(2):343-356.

89.   Person V, Kostin S, Suzuki K, Labeit S, Schaper J. Antisense oligonucleotide experiments elucidate the essential role of titin in sarcomerogenesis in adult rat cardiomyocytes in long-term culture. J Cell Sci. 2000;113 Pt 21:3851-3859.

90.   Kotaka M, Kostin S, Ngai S, Chan K, Lau Y, Lee SM, Li H, Ng EK, Schaper J, Tsui SK, Fung K, Lee C, Waye MM. Interaction of hCLIM1, an enigma family protein, with alpha-actinin 2. J Cell Biochem. 2000;78(4):558-565.

91.   Kostin S, Hein S, Arnon E, Scholz D, Schaper J. The cytoskeleton and related proteins in the human failing heart. Heart Fail Rev. 2000;5(3):271-280.

92.   Kostin S. The structural correlate of reduced cardiac function in failing human hearts. In: Takeda N, Nagano M, Dhalla NS, eds. The hypertrophied heart. Boston: Kluwer Academic Publisher; 2000:423-439.

93.   Heling A, Zimmermann R, Kostin S, Maeno Y, Hein S, Devaux B, Bauer E, Klovekorn WP, Schlepper M, Schaper W, Schaper J. Increased expression of cytoskeletal, linkage, and extracellular proteins in failing human myocardium. Circulation research. 2000;86(8):846-853.

94.   Hein S, Kostin S, Heling A, Maeno Y, Schaper J. The role of the cytoskeleton in heart failure. Cardiovascular research. 2000;45(2):273-278.

95.   Freude B, Masters TN, Robicsek F, Fokin A, Kostin S, Zimmermann R, Ullmann C, Lorenz-Meyer S, Schaper J. Apoptosis is initiated by myocardial ischemia and executed during reperfusion. Journal of molecular and cellular cardiology. 2000;32(2):197-208.

96.   Fernandez B, Buehler A, Wolfram S, Kostin S, Espanion G, Franz WM, Niemann H, Doevendans PA, Schaper W, Zimmermann R. Transgenic myocardial overexpression of fibroblast growth factor-1 increases coronary artery density and branching. Circulation research. 2000;87(3):207-213.

97.   Elsasser A, Decker E, Kostin S, Hein S, Skwara W, Muller KD, Greiber S, Schaper W, Klovekorn WP, Schaper J. A self-perpetuating vicious cycle of tissue damage in human hibernating myocardium. Mol Cell Biochem. 2000;213(1-2):17-28.

98.   Cai W, Vosschulte R, Afsah-Hedjri A, Koltai S, Kocsis E, Scholz D, Kostin S, Schaper W, Schaper J. Altered balance between extracellular proteolysis and antiproteolysis is associated with adaptive coronary arteriogenesis. Journal of molecular and cellular cardiology. 2000;32(6):997-1011.

99.   Schaper J, Elsasser A, Kostin S. The role of cell death in heart failure. Circulation research. 1999;85(9):867-869.

100. Kubin T, Ando H, Scholz D, Bramlage P, Kostin S, van Veen A, Heling A, Hein S, Fischer S, Breier A, Schaper J, Schaper W. Microvascular endothelial cells remodel cultured adult cardiomyocytes and increase their survival. Am J Physiol. 1999;276(6 Pt 2):H2179-2187.

101. Kostin S, Hein S, Bauer EP, Schaper J. Spatiotemporal development and distribution of intercellular junctions in adult rat cardiomyocytes in culture. Circulation research. 1999;85(2):154-167.

102. Kostin S, Calenich O, Groppa L, Popovich M. Myocarditis or inflammatory cardiomyopathy: definition, ethiopathological description and clinicopathological classification. Curr Med. 1999;9:81-85.

103. Schwarz ER, Schoendube FA, Kostin S, Schmiedtke N, Schulz G, Buell U, Messmer BJ, Morrison J, Hanrath P, vom Dahl J. Prolonged myocardial hibernation exacerbates cardiomyocyte degeneration and impairs recovery of function after revascularization. Journal of the American College of Cardiology. 1998;31(5):1018-1026.

104. Millevoi S, Trombitas K, Kolmerer B, Kostin S, Schaper J, Pelin K, Granzier H, Labeit S. Characterization of nebulette and nebulin and emerging concepts of their roles for vertebrate Z-discs. J Mol Biol. 1998;282(1):111-123.

105. Kostin S, Scholz D, Shimada T, Maeno Y, Mollnau H, Hein S, Schaper J. The internal and external protein scaffold of the T-tubular system in cardiomyocytes. Cell Tissue Res. 1998;294(3):449-460.

106. Kostin S, Heling A, Hein S, Scholz D, Klövekorn WP, Schaper J. The protein composition of the normal and diseased cardiac myocyte. Heart Fail Rev. 1998;2:245-260.

107. Hein S, Kostin S, Bauer EP, Klövekorn WP, Schaper J. Das Zytoskelett des Kardiomyozyten in normalen und insuffizienten menschlichen Myokard. II. Membran assozierte Proteinen. Kardiovask Med. 1998;2:78-95.

108. Hein S, Kostin S, Bauer EP, Klövekorn WP, Schaper J. Das Zytoskelett des Kardiomyozyten in normalen und insuffizienten menschlichen Myokard. I. Sarcomere und Zytoplasma. Kardiovask Med. 1998;2:7-22.

109. Freude B, Masters TN, Kostin S, Robicsek F, Schaper J. Cardiomyocyte apoptosis in acute and chronic conditions. Basic Res Cardiol. 1998;93(2):85-89.

110. Florya VG, Popovich MI, Kostin SI, Severin VV, Mareev VY, Belenkov YN. Remodeling of peripheral blood vessels accompanies development of chronic heart failure in patients with ischemic heart disease. Kardiologya. 1998;38:14-19.

111. Schaper J, Scholz D, Devaux B, Schönburg M, Kostin S, Winkler B, Ando H. The morphology and structure of the coronary vasculature. In: Haunso S, Aldershvile J, Svendsen JH, eds. Coronary microcirculation during ischaemia and reperfusion. Copenhagen: Munksgaard; 1997:17-33.

112. Saulea A, Kostin S, Rotari V. Heart ultrastructure in experimental acute myocarditis. Rom J Physiol. 1997;34(1-4):35-44.

113. Elsasser A, Schlepper M, Klovekorn WP, Cai WJ, Zimmermann R, Muller KD, Strasser R, Kostin S, Gagel C, Munkel B, Schaper W, Schaper J. Hibernating myocardium: an incomplete adaptation to ischemia. Circulation. 1997;96(9):2920-2931.

114. Popovich MI, Kobets VA, Kostin S, Kapelko VI. Restoration of ultrastructure and function of the rat heart after catecholamine injury. Kardiologya. 1995;35:61-63.

115. Popovich MI, Kobets VA, Kostin S, Kapelko VI. Functional state of the heart caused by fluoride poisoning. Kardiologya. 1995;35:50-53.

116. Popovich M, Kostin S, Branishte T, Kobets V, Kapelko V. Cellular hypertrophy in cardiomyopathic patients is associated with lower creatine-stimulated mitochondrial respiration. Mol Cell Biochem. 1995;143(1):1-5.

117. Popovich MI, Kobets VA, Kostin SI, Kapelko VI. Protective effect of taurine on the myocardial effects of prolonged treatment with norepinephrine in rats. Cardioscience. 1992;3(1):61-66.

118. Popovich MI, Kobets VA, Kostin SI, Kapelko VI. Myocardial alterations induced by prolonged noradrenaline administration in various doses. Clin Cardiol. 1992;15(9):660-665.

119. Samsonov M, Nassonov E, Kostin S, Samko A, Alexandrova L, Masenko V, Naumov V, Mareev V, Shevlyagin S, Zhdanov V. Serum neopterin--possible immunological marker of myocardial inflammation in patients with dilated heart muscle disease. Eur Heart J. 1991;12 Suppl D:151-153.

120. Popovich M, Kostin S, Kobets V, Kapelko V. Protective effect of taurine on myocardial alterations induced by prolonged noradrenaline treatment. Cardioscience. 1991;1:11-16.

121. Kapelko VI, Popovich MI, Kostin SI, Golikov MA, Sharov VG, Saks VA. The ultrastructural, metabolic and functional alterations of the heart at prolonged adriamycin treatment. J Appl Cardiol. 1989;4:79-89.

122. Kostin S. Morphologic and morphometric characteristics of hypertrophic cardiomyopathy. Arkh Patol. 1989;51(11):47-53.

123. Kostin S. The use of endomyocardial biopsy in diagnosing cardiomyopathy and myocarditis. Arkh Patol. 1989;51(6):88-93.