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Research Article
 
DOI:10.11909/j.issn.1671-5411.2019.11.003
Association between big endothelin-1 and CHADS2/CHA2DS2-VASc scores in non-valvular atrial fibrillation
Li-Hui ZHENG,Shang-Yu LIU,Feng HU,Er-Peng Liang,Ling-Min WU,Hong-Lei WANG,Ammar M Killu,Yan YAO.Relationships of big endothelin-1 with CHADS2 and CHA2DS2-VASc scores in non-valvular Atrial FibrillationJ Geriatr Cardiol 2019,16(11):812~817
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Authors:Li-Hui ZHENG1;Shang-Yu LIU1;Feng HU1;Er-Peng Liang1;Ling-Min WU1;Hong-Lei WANG2;Ammar M Killu3;Yan YAO4

Author Affiliation:1.Clinical EP Lab & Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;2.The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China;3.Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA;4.Clinical EP Lab & Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Foundation:

Abstract: Background Endothelial function, as measured by big endothelin-1 (ET-1), has been demonstrated to be useful in predicting adverse long-term events in patients with cardiovascular disease. Nevertheless, there are little data about the association between big ET-1 and thromboembolism risk in atrial fibrillation (AF). We aimed to investigate the relationship between big ET-1 and CHADS2/CHA2DS2-VASc scores used for evaluating thromboembolic risk in patients with non-valvular AF. Methods The study population consisted of 238 consecutive AF patients (67.6% with paroxysmal AF and 32.4% with persistent AF). The patients were divided into two groups (high- or low-intermediate risk group) based on CHADS2 and CHA2DS2-VASc scores (score ≥2 or < 2, respectively). Clinical, laboratory, and echocardiographic parameters were evaluated, and the CHADS2/CHA2DS2-VASc scores were compared between groups. The association between big ET-1 levels and CHADS2/CHA2DS2-VASc score was assessed. Multivariate logistic regression analysis was performed to identify independent predictors of CHADS2/CHA2DS2-VASc scores. Results The high CHADS2/CHA2DS2-VASc score group had older age, higher big ET-1 levels, and enlarged left atrial diameter than the low CHADS2/CHA2DS2-VASc score group (P < 0.05). Multiple logistic regression analysis revealed that big ET-1 level was an independent determinant of high CHADS2/CHA2DS2-VASc scores [odds ratio (OR) = 2.545 and OR = 3.816; both P < 0.05]. Conclusions Our study indicates that in non-valvular AF, big ET-1 was significantly correlated with CHADS2/CHA2DS2-VASc scores and an independent predictor of high CHADS2/CHA2DS2-VASc scores. Big ET-1 may serve as a useful marker for risk stratification in this setting.

Keywords:

Atrial fibrillation; Cardiac risk factors; Stroke; Prevention
Received:July 11, 2019        Accepted:October 23, 2019   Published Online:November 28, 2019
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