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Review
 
DOI:doi:10.11909/j.issn.1671-5411.2017.11.006
The role of immune abnormality in depression and cardiovascular disease
Ru–Hui LIU,Jiang–Qi PAN,Xian–E TANG,Bing LI,Shang–Feng LIU,Wen–Lin MA.The role of immune abnormality in depression and cardiovascular diseaseJ Geriatr Cardiol 2017,14(11):703~710
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Authors:Ru–Hui LIU1;Jiang–Qi PAN1;Xian–E TANG1;Bing LI2;Shang–Feng LIU3;Wen–Lin MA4

Author Affiliation:1.Department of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China;2.Department of Hematology, Tongji Hospital, Tongji University School of Medicine; Shanghai, China;3.Department of Stomatology, Huashan Hospital, Fudan University, Shanghai,;4.Department of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China

Foundation:

Abstract: Depression and cardiovascular disease (CVD) are both highly prevalent disorders, and some evidence shows that there is a ‘vi-cious cycle’ linking major depression and CVD. There is also growing evidence that immune abnormalities underpin the common pathophysiology of both CVD and major depression. The abnormalities include the following: abnormal levels of inflammatory mark-ers, such as interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor α (TNF-α) and interleukin-12 (IL-12); increased acute phase proteins, such as C-reactive protein, fibrinogen and haptoglobin; and abnormal complement factors. The findings show that ma-jor depression and CVD patients have greater immune abnormalities, which may increase depressive symptoms and cardiovascular pathological changes, and that there may be a bidirectional relationship, therefore more prospective studies are needed to draw conclu-sions.

Keywords:

Cardiovascular disease; Depression; Immune abnormality
Received:July 20, 2017        Accepted:September 08, 2017   Published Online:November 28, 2017
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