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Research Article
 
DOI:doi:10.11909/j.issn.1671-5411.2017.11.004
Independent and combined effects of environmental factors and miR-126, miR-143, and miR-145 on the risk of coronary heart disease
Da–Cen LIN,Jia–Bing LIN,Zhou CHEN,Rong CHEN,Chun–Yu WAN,Shao–Wei LIN,Qi–Shuang RUAN,Huang–Yuan LI,Si–Ying WU.Independent and combined effects of environmental factors and MiR-126, MiR-143, and MiR-145 on the risk of coronary heart diseaseJ Geriatr Cardiol 2017,14(11):688~695
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Authors:Da–Cen LIN1;Jia–Bing LIN1;Zhou CHEN2;Rong CHEN3;Chun–Yu WAN3;Shao–Wei LIN3;Qi–Shuang RUAN4;Huang–Yuan LI5;Si–Ying WU6

Author Affiliation:1.Department of Epidemiology and Health Statistics, the Key Laboratory of Environment and Health among Universities and Colleges in Fujian, School of Public Health, Fujian Medical University, Minhou County, Fuzhou, Fujian, China;2.Affiliated People 's Hospital of Fujian University of Traditional Chinese Medicine, Fujian, China;3.Department of Epidemiology and Health Statistics, the Key Laboratory of Environment and Health among Universities and Colleges in Fujian, School of Public Health, Fujian Medical University, Minhou County, Fuzhou, Fujian, China;4.Fujian Medical University Union Hospital, Fujian, China;5.Department of Preventive Medicine, Research Unit for Toxicology and Chemical Safety Assessment, Institution of Environmental and Health, Major Sub-ject of Environment and Health of Fujian Key Universities, School of Public Health, Fujian Medical University, Fujian, China;6.Department of Epidemiology and Health Statistics, the Key Laboratory of Environment and Health among Universities and Colleges in Fujian, School of Public Health, Fujian Medical University, Minhou County, Fuzhou, Fujian, China

Foundation:

Abstract: Objective to evaluate the effects of environmental factors and microRNAs (miRNAs) (miR-126, miR-143, and miR-145) on the risk of coronary heart disease (CHD). Methods A frequency-matched case-control study (450 patients, 450 controls) was conducted from April 2014 to December 2016 in Fuzhou City, China. Environmental factors were investigated using a self-administered questionnaire, and the expression levels of miR-126, miR-143, and miR-145 were determined by quantitative real-time Polymerase Chain Reaction (PCR) in peripheral blood mononuclear cells. Unconditional logistic regression models were used for statistical evaluation. Results Alcohol consumption, high-salt diets, high-intensity work, and lack of physical activity were significantly associated with increased CHD risk, whereas light diet was significantly associated with decreased risk. MiR-126, miR-143, and miR-145 were highly expressed in the CHD group compared with the control group. After adjustment for other environmental factors, unconditional logistic regression results revealed that miR-126, miR-143, and depression were the independent risk factors of CHD, and light diet was the independent protective factor of CHD. Conclusions Our data suggest that a family history of CHD, anxiety, and alcohol consumption was significantly associated with increased CHD risk, whereas light diet was significantly associated with decreased risk. Furthermore, miR-126 and miR-143 in combination with several risk factors, could play a joint role in the development of CHD. Therefore, it is necessary to manage patients with CHD in all directions and multiple level.

Keywords:

Case-control study; Coronary heart disease; Environmental factors; Gene-environment interaction; MiR-126; MiR-143; MiR-145
Received:January 03, 2017        Accepted:September 01, 2017   Published Online:November 28, 2017
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