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Research Article                                                                                             Online First
 
DOI:doi:10.11909/j.issn.1671-5411.2016.03.020
The effect of percutaneous coronary intervention on endothelial function
Page view: 2112        
Authors:Ming GAO1;Yu-Qi LIU2;Feng TIAN2;Geng QIAN2;Yun-Dai CHEN2

Author Affiliation:1.Department of Cardiology, Chinese PLA General Hospital, Beijing, China; School of Medicine, Nankai University, Tianjin, China;2.Department of Cardiology, Chinese PLA General Hospital, Beijing, China;

Foundation:

Abstract: Objectives To evaluate the effect of percutaneous coronary intervention (PCI) on endothelial function. Background Endothelial injury following PCI remains one of the most common problems. Although previous studies have demonstrated that PCI is usually followed by endothelial damage/dysfunction, the characteristics and influence factors of the changes in endothelial function are not clear except for some biomarkers in blood. Methods We performed an observational study on 75 patients including 25 patients undergoing diagnostic coronary angiography and 50 patients undergoing stent-based PCI. In data analysis, we further divided the 50 patients into short-stent group and long-stent group according to the total length of stents. Flow-mediated dilation (FMD) and nitroglycerin-mediated dilation were recorded preoperatively, and at 24 h after procedure, as well as three blood biomarkers high-sensitivity C-reactive protein, von Willebrand Factor (vWF) and Interleukin-6. Results After PCI, FMD deteriorated much more significantly in long-stent group than in short-stent group (FMD: 3.2 ± 1.2 vs. 1.6 ± 1.0%, P < 0.01), whereas FMD did not change significantly in coronary angiography group (9.1 ± 2.0 vs. 8.3 ± 2.5%, P = 0.081). In addition, an elevation of vWF following PCI was observed both in long-stent group (170 ± 79 vs. 207 ± 95 IU/dL, P < 0.001) and short-stent group (172 ± 69 vs. 194 ± 50 IU/dL, P = 0.008). Significant positive correlation existed between the decrease of FMD and increase of vWF (r = 0.328, P = 0.020). Multiple linear regression analysis showed that FMD deterioration is significantly correlated with total stent length (P = 0.001) and total dilation pressure (P = 0.036). Conclusions A remarkable deterioration of FMD and a proportional increase in vWF level in our study suggests that PCI induced the impairment of endothelial function. The extent of endothelial dysfunction is correlated with stent length and the total dilation pressure.

Keywords:

Coronary stent implantation; Endothelial dysfunction; Flow-mediated dilation; von Willebrand Factor
Received:December 15, 2015        Accepted:March 15, 2016   Published Online:March 29, 2016
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