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Research Article
 
DOI:doi:10.11909/j.issn.1671-5411.2015.02.001
Relationship between lipoprotein (a) and micro/macro complications in type 2 diabetes mellitus: a forgotten target
Rocio Toro,Eduardo Segura,Jesus Millan Nunez-Cortes,Juan Carlos Pedro-Botet,Maribel Quezada-Feijoo,Alipio Mangas.Relationship between lipoprotein (a) and micro/macro complications in type 2 diabetes mellitus: a forgotten targetJ Geriatr Cardiol 2015,12(2):93~99
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Authors:Rocio Toro1;Eduardo Segura2;Jesus Millan Nunez-Cortes3;Juan Carlos Pedro-Botet4;Maribel Quezada-Feijoo5;Alipio Mangas6

Author Affiliation:1.Medicine Department, School of Medicine, Cadiz University, Cadiz, Spain;2.Medicine Department, School of Medicine, Cadiz University, Cadiz, Spain; Universitary Hospital Puerta del Mar, Cadiz, Spain;3.Chief of Internal Medicine Department. Universitary Hospital Gregorio Maranon, Madrid, Spain;4.Hospital del Mar, Barcelona, Spain;5.Cruz Roja Hospital, Madrid, Spain;6.Medicine Department, School of Medicine, Cadiz University, Cadiz, Spain; Universitary Hospital Puerta del Mar, Cadiz, Spain

Foundation:

Abstract: Objectives Increased lipoprotein (a) serum concentrations seems to be a cardiovascular risk factor; this has not been confirmed in extracoronary atherosclerosis complications. We therefore wished to gain a deeper insight into relationship between the plasma concentra-tions of lipoprotein (a) and the micro- and macro-vascular complications of type 2 diabetes mellitus and to identify possible differences in this association. Methods This is a descriptive observational cross-sectional study. Two-hundred and seventeen elderly patients with type 2 diabetes mellitus were included from the internal medicine outclinic. Anthropometric data, analytical data (insulin reserve, basal and post-prandial peptide C, glycosylated hemoglobin, renal parameters, lipid profile and clinical data as hypertension, obesity, micro- and macrovas-cular complications were collected. Results Patients were grouped according to the type 2 diabetes mellitus time of evolution. The mean plasma concentration of lipoprotein (a) was 22.2 ± 17.3 mg/dL (22.1 ± 15.9 mg/dL for males, and 22.1 ± 18.4 mg/dL for females). Patients with hypertension, coronary heart disease, cerebrovascular accident, microalbuminuria and proteinuria presented a statistically significant increased level of lipoprotein (a). Similarly, the patients with hyperlipoprotein (a) (≥ 30 mg/dL) presented significantly increased levels of urea and total cholesterol. In the multivariate regression model, the level of lipoprotein (a) is positively correlated with coronary heart disease and diabetic nephropathy (P < 0.01 and P < 0.005, respectively). Conclusions The elevation of plasma levels of lipoprotein (a) are associated with the development of coronary heart disease and diabe tic nephropathy. Therefore, we consider that the determination of lipoprotein (a) may be a prognostic marker of vascular complications in patients with type 2 diabetes mellitus.

Keywords:

Lipoprotein (a); Macrovascular complications; Risk factors; Type 2 diabetes
Received:September 17, 2017        Accepted:January 17, 2015   Published Online:February 10, 2015
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