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Research Article
 
DOI:10.3969/j.issn.1671-5411.2013.03.001
Serum cystatin C concentration as an independent marker for hypertensive left ventricular hypertrophy
Xin Li,Hang Zhu,Peng Li,Qian Xin,Jie Liu,Wei Zhang,You-Hong Xing,Hao Xue.Serum Cystatin C Concentration as an Independent Marker for Hypertensive Left Ventricular HypertrophyJ Geriatr Cardiol 2013,10(3):286~290
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Authors:Xin Li1;Hang Zhu2;Peng Li3;Qian Xin4;Jie Liu4;Wei Zhang4;You-Hong Xing4;Hao Xue4

Author Affiliation:1.Clinical Department of Medicine, Chinese PLA General Hospital, Beijing 100853, China;2.Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China;3.Clinical Department of Medicine, Chinese PLA General Hospital, Beijing 100853, China;4.Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China;

Foundation:

Abstract: Background Serum cystatin C levels can be used to predict morbidity and mortality in patients with cardiovascular disease. However, the clinical relevance of serum cystatin C levels in patients with hypertensive left ventricular hypertrophy (LVH) has rarely been investigated. We designed the present study to investigate whether serum cystatin C levels are associated with cardiac structural and functional alterations in hypertensive patients. Methods We enrolled 823 hypertensive patients and classified them into two groups: those with LVH (n = 287) and those without LVH (n = 536). All patients underwent echocardiography and serum cystatin C testing. We analyzed the relationship between serum cystatin C levels and LVH. Results Serum cystatin C levels were higher in hypertensive patients with LVH than in those without LVH (P < 0.05). Using linear correlation analysis, we found a positive correlation between serum cystatin C levels and interventricular septal thickness (r = 0.247, P < 0.01), posterior wall thickness (r = 0.216, P < 0.01), and left ventricular weight index (r = 0.347, P < 0.01). When analyzed by multiple linear regression, the positive correlations remained between serum cystatin C and interventricular septal thickness (β = 0.167, P < 0.05), posterior wall thickness (β = 0.187, P < 0.05), and left ventricular weight index (β = 0.245, P < 0.01). Conclusion Serum cystatin C concentration is an independent marker for hypertensive LVH.

Keywords:

Hypertension; Left ventricular hypertrophy; Cystatin C
Received:March 06, 2013        Accepted:June 27, 2013   Published Online:June 30, 2013
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