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Review
 
DOI:10.3969/j.issn.1671-5411.2013.01.015
High-sensitive cardiac troponin T
Ru-Yi Xu,Xiao-Fa Zhu,Ye Yang,Ping Ye.J Geriatr Cardiol 2013,10(1):102~109
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Authors:Ru-Yi Xu1;Xiao-Fa Zhu1;Ye Yang1;Ping Ye2

Author Affiliation:1.Department of Geriatric Cardiology, Navy General Hospital, No.6, Fucheng Road, Beijing 100048, China;2.Department of Geriatric Cardiology, Chinese PLA General Hospital, No.28, Fuxing Road, Beijing 100853, China

Foundation:

Abstract: Cardiac troponin is the preferred biomarker for the diagnosis of acute myocardial infarction (AMI). The recent development of a high-sensitive cardiac troponin T (hs-cTnT) assay permits detection of very low levels of cTnT. Using the hs-cTnT assay improves the overall diagnostic accuracy in patients with suspected AMI, while a negative result also has a high negative predictive value. The gain in sensitivity may be particularly important in patients with a short duration from symptom onset to admission. Measurement of cardiac troponin T with the hs-cTnT assay may provide strong prognostic information in patients with acute coronary syndromes, stable coronary artery disease, heart failure and even in the general population; however, increased sensitivity comes at a cost of decreased specificity. Serial testing, as well as clinical context and co-existing diseases, are likely to become increasingly important for the interpretation of hs-cTnT assay results.

Keywords:

Troponin T; Acute myocardial infarction; Risk stratification
Received:November 10, 2012        Accepted:February 26, 2013   Published Online:March 28, 2013
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